Status of Cardiovascular Health in Chinese Adults

Bi, Yufang; Jiang, Yong; He, Jiang; Xu, Yu; Wang, Limin; Xu, Min; Zhang, Mei; Li, Yichong; Wang, Tiange; Dai, Meng; Lu, Jieli; Li, Mian; Chen, Chung-Shiuan; Lai, Shenghan; Wang, Weiqing; Wang, Lınhong; Ning, Guang

doi:10.1016/j.jacc.2014.12.044

Cited by 146 publications

(114 citation statements)

References 38 publications

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“…Ischemic heart disease (IHD) is a public health concern with a rising incidence that leads to high morbidity and mortality worldwide, which is closely associated with cardiac dysfunctions, especially myocardial infarction, ischemia reperfusion injury and heart failure [1]. It is widely accepted that myocardial ischemia (MI) injury is a pathological process that includes energy deficit, inflammation, oxidative stress, cardiomyocyte death, involving inherently multiple and complex signaling pathways [2].…”

Section: Introductionmentioning

confidence: 99%

A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia

Li¹,

Fan²,

Cai³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization. Therefore, it is necessary to develop new modern drugs based on the combination of effective components in TCM with exact clinical efficacy. In present study, we aimed to detect optimal ratio of the combination of effective components based on Sheng-Mai-San for myocardial ischemia. Methods: On the basis of preliminary studies and references of relevant literature about Sheng-Mai-San for myocardial ischemia, we chose three representative components (ginsenoside Rb1 (G), ruscogenin (R) and schisandrin (S)) for the optimization design studies. First, the proper proportion of the combination was explored in different myocardial ischemia mice induced by isoproterenol and pituitrin based on orthogonal design. Then, the different proportion combinations were further optimized through uniform design in a multi-model and multi-index mode. Finally, the protective effect of combination was verified in three models of myocardial ischemia injured by ischemia/reperfusion, chronic intermittent hypoxia and acute infarction. Results: The optimized combination GRS (G: 6 mg/kg, R: 0.75 mg/kg, S: 6 mg/kg) obtained by experimental screening exhibited a significant protective effect on myocardial ischemia injury, as evidenced by decreased myocardium infarct size, ameliorated histological features, decreased myocardial myeloperoxidase (MPO) and malondiadehyde (MDA), calcium overload, and decreased serum lactate dehydrogenase (LDH), creatine kinase MB isoenzyme (CK-MB), cardiac troponin I (cTn-I) activity. In addition, the interactions of three components in combination GRS were also investigated. The combination, compared to G, R and S, could significantly reduce the concentration of serum CK-MB and cTn-I, and decrease myocardial infarct size, which demonstrated the advantages of this combination for myocardial ischemia. Conclusion: Our results demonstrated that the optimized combination GRS could exert significant cardioprotection against myocardial ischemia injury with similar effect compared to Sheng Mai preparations, which might provide some pharmacological evidences for further development of new modern Chinese drug for cardiovascular diseases basing on traditional Chinese formula with affirmative therapeutic effect.

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Section: Introductionmentioning

confidence: 99%

A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia

Li¹,

Fan²,

Cai³

et al. 2018

Cell Physiol Biochem

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“…1 In 2010, the percentage of ideal cardiovascular health in Chinese adults was estimated at 0.2% (0.1% in men and 0.4% in women). 2 Although the clinical manifestations of CVD occur in adulthood, the atherosclerotic process begins during childhood.…”

Section: Introductionmentioning

confidence: 99%

Waist Circumference, Health-Related Physical Fitness, and Cardiovascular Disease Risk Factors in Chinese Adolescents

Chen¹

2017

MOJPH

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This study aimed to examine differences in CVD risk factors across four crosstabulated groups according to health-related physical fitness index (PFI, composite index of standing long jump, 50-m test, and 800-or 1000-m run/walk) and waist circumference (WC) in Guangzhou youth. Participants comprised 588 males and 579 females aged 11-18years from Guangzhou, China. They were cross-tabulated into four groups according to WC and PFI, namely, Low-WC/High-PFI, High-WC/Low-PFI, Low-WC/Low-PFI, and High-WC/High-PFI. A CVD risk score was derived from six established CVD risk factors, i.e., blood pressure (BP), triglycerides (TG), fasting total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and TC: HDL-C. For both genders, lower BP values were observed in the Low-WC group compared with the High-WC group with the same fitness level (p<0.05). In boys, participants in the Low-WC/Low-PFI group also had lower BP than those in the High-WC/High-PFI group (p<0.05). Lower TC, LDL-C, TC: HDL-C, and higher HDL-C were also found in the Low-WC groups than in the High-WC groups in boys (p<0.05). A general trend of lower blood lipids and glucose for both boys and girls in the High-PFI group compared with the Low-PFI group was also observed. Higher CVD risk scores were only observed in the High-WC group compared with the Low-WC group with the same PFI level for boys (p<0.05). We can concluded that clustering of CVD risk factors was inversely related to WC, and physical fitness may play a positive effect on reducing the hazards of abdominal obesity.

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“…The authors defined this "as the simultaneous presence of four favorable health behaviors (ideal smoking status, ideal BMI, physical activity at goal, and healthy dietary habits) and four favorable health factors (ideal smoking status, untreated total cholesterol <200 mg/dL, untreated blood pressure <120/<80 mm Hg, and untreated fasting plasma glucose <100 mg/dL) in the absence of cardiovascular disease history." [2] Rapid economic development in China has influenced adverse trends in lifestyle, including increased intake of saturated fat, physical inactivity, and smoking (especially among men). As a result, Drs.…”

mentioning

confidence: 99%

“…Bi and Ning noted that nearly 3 out of 4 Chinese adults have poor cardiovascular health. [2] The prevalence of diabetes in China is also on the rise, more than doubled over the past decade. Without intervention, the number of Chinese with diabetes is expected to rise to 42.3 million by 2030.…”

mentioning

confidence: 99%

“…"China is the most populous country in the world, and changes in disease prevalence in the Chinese population will significantly affect the global burden of disease," wrote Dr. Bi and colleagues. [2] It is crucial to identify Chinese populations who are not only at risk, but who will benefit the most from prevention measures like smoking cessation, glucose and weight control, increased physical activity, and/ or high blood pressure or lipid-lowering treatments.…”

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confidence: 99%

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China may hold answers to addressing cardiovascular disease epidemic

Chazal

2016

Journal of Translational Internal Medicine

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Status of Cardiovascular Health in Chinese Adults

Abstract: The percentage of ideal cardiovascular health in Chinese adults is extremely low. Both population-wide and high-risk strategies should be implemented with great effort to promote cardiovascular health in China.

Cited by 146 publications

References 38 publications

A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia

A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia

Waist Circumference, Health-Related Physical Fitness, and Cardiovascular Disease Risk Factors in Chinese Adolescents

China may hold answers to addressing cardiovascular disease epidemic

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