Status of children with cow's milk allergy in infancy by 10 years of age

Tikkanen, S; Kokkonen, Jorma; Juntti, Hanna; Niinimäki, Aila

doi:10.1111/j.1651-2227.2000.tb00731.x

Cited by 28 publications

(15 citation statements)

References 18 publications

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“…Curiously, Tikkanen et al. (20) compared 56 10‐yr‐old children with CMA with age‐matched healthy controls and showed that CMA in infancy increases the risk of developing other atopic diseases and allergic sensitization with a natural course that is independent of the eventual persistence of CMA.…”

Section: Discussionmentioning

confidence: 99%

Predictive factors for the persistence of cow’s milk allergy

Santos

Dias²,

Pinheiro³

2010

Pediatric Allergy Immunology

116

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Cow's milk allergy (CMA) is usually transient, but recent studies have shown a later acquisition of tolerance to CM. Our aims were to characterize a population of Portuguese children with CMA and to identify predictive factors for the persistence of this food allergy. Children with CMA observed in our Paediatric Allergy Clinic between 1997 and 2006 were selected. Demographic and clinical data were collected from medical records. The group of children who tolerated CM before the age of 2 was compared with the group of children who tolerated CM beyond that age or persisted with CMA until the end of the study. Multivariate logistic regression analysis was used to investigate independent predictive factors for the persistence of CMA beyond the age of 2. In the subgroup of children with IgE-mediated CMA, the acquisition of tolerance was analysed using Cox regression. In this population of 139 children, the majority presented more than one symptom (73%) affecting more than one organ (51%), with cutaneous (81%), gastrointestinal (55%), respiratory (16%) manifestations and/or anaphylaxis (3%). Thirty-two per cent developed asthma, 20% atopic eczema, 20% rhinoconjunctivitis and 19% other food allergies over time. The acquisition of tolerance was different in the whole population versus the subgroup with IgE-mediated CMA: 34%versus 0% at the age of 2, 55%versus 22% at the age of 5 and 68%versus 43% at the age of 10. Immediate allergic symptoms, asthma and other food allergies were independent factors for the persistence of CMA beyond the age of 2. Higher maximum weal diameter on skin prick test to CM and higher maximum level of specific IgE to CM were associated with reduced likelihood of acquiring tolerance in the subgroup of children with IgE-mediated CMA. In conclusion, children with IgE-mediated CMA acquire tolerance to CM at older age. Clinical parameters and allergy tests may be helpful in defining prognosis. CM-allergic children tend to develop other atopic conditions and need specialized follow-up in the long term.

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Section: Discussionmentioning

confidence: 99%

Predictive factors for the persistence of cow’s milk allergy

Santos

Dias²,

Pinheiro³

2010

Pediatric Allergy Immunology

116

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“…In this context it is interesting to note that, in some children affected by cow milk allergy during infancy, a local ratio of gastrointestinal diseases, such as recurrent abdominal pain, may persist 22,23.…”

Section: Discussionmentioning

confidence: 99%

A prospective 10‐year study on children who had severe infantile colic

et al. 2005

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Aim: To evaluate the association between infantile colic and gastrointestinal, allergic and psychological disorders in childhood. Methods: A prospective study was conducted on 103 infants aged 31–87 d. After 10 y, between 2001 and 2003, the children were recalled and a paediatrician evaluated the selected disorders by anamnesis, medical examination, laboratory tests and parent interviews. Results: Of the 103 infants enrolled, 96 completed the study. There was an association between infantile colic and recurrent abdominal pain (p=0.001) and allergic disorders: allergic rhinitis, conjunctivitis, asthmatic bronchitis, pollenosis, atopic eczema and food allergy (p<0.05). Sleep disorders, fussiness, aggressiveness and feelings of supremacy are more frequent in children who suffered from colic during early infancy (p<0.05). A family history of gastrointestinal diseases and atopic diseases was significantly higher in infants with colic than in controls (p<0.05). Conclusion: Susceptibility to recurrent abdominal pain, allergic and psychological disorders in childhood may be increased by infantile colic. Our findings confirm that severe infantile colic might be the early expression of some of the most common disorders in childhood.

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“…En nuestro estudio, la presencia de antecedentes familiares de atopia fue inferior a la reflejada en otros 8,11 . El porcentaje de pacientes que presentaba más de una manifestación atópica fue similar a otros estudios 12 . El porcentaje que alcanzó tolerancia fue similar al encontrado por Dias 13 en Portugal a los diez años, aunque en sus estudios no todos presentan alergia IgEmediada, lo mismo ocurría con la muestra del estudio de Tikkanen 12 .…”

Section: Resultsunclassified

“…El porcentaje de pacientes que presentaba más de una manifestación atópica fue similar a otros estudios 12 . El porcentaje que alcanzó tolerancia fue similar al encontrado por Dias 13 en Portugal a los diez años, aunque en sus estudios no todos presentan alergia IgEmediada, lo mismo ocurría con la muestra del estudio de Tikkanen 12 . En nuestro estudio existe una tendencia a que los niños con manifestaciones respiratorias de atopia (asma y/o rinoconjuntivitis) alcancen la tolerancia más tarde.…”

Section: Resultsunclassified