Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

Abstract

There are numerous growing evidences of resemblance between carcinomas of the breast and prostate. A total of 48 cases of these two hormone-dependent cancers along with approprlats controls were subjected for status of epidermal growth factor receptors as well as serum lipid profile. Paraffin embedded tissue sections from afonmald tumum were analysed by immunohistochemical stuining for epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotsin, nslxogen mcapt~ (ER) and Wogestmmne receptor (PgR). Sere from same individuals were studied for serum lipid profile analysis. The study revealed that immunoexpression of all receptor proteins (EGF-R). c-erbB-2 was significantly higher in breast carcinoma. In addition, mean levels of triglyc~Ntdas, total cholesterol, LDL-cholestsrol were found to be significantly elevated while the level of HDL-cholesterol was observed to be lower among patients with breast cancer as compared to matched oonlxols. Further, ER-posilive breast cancar cases have significant~ higher mean level of HDL-cholasterol when compared with ER-negative breast cancer patients. Contrary to this, no alteration in different serum lipid fractions was noticed among the patients with prostate cancer. However, a positive relationship was noticed between immunoexpressions of EGF-R and c-erbB-2 in prostate cancer.KEY WORDS : EGF-R, c-err6-2, lipids, breast cancer and prostate cancer.

Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment

“…Nonetheless, regarding metabolic syndrome-related parameters, significantly elevated triglycerides and decreased HDL-cholesterol levels were recorded among breast cancer cases than lean controls [155]. Likewise, Jain et al [156] observed similarly altered levels of relevant blood lipid fractions, though these parameters did not correlate significantly with HER2 expression in breast cancer. On the other hand, a study on lipid metabolism-related proteins/enzymes in metastatic breast cancer revealed an association of HER2 positivity with FASN and acyl-CoA oxidase 1 [157].…”

Serum total PSA and free PSA in breast tumors

“…The role of Insulin Like Growth Factors (IGF) and estrogen on insulin level has also been suggested for the alteration of glucose metabolism in breast cancer cases [18][19][20]. Several studies have also documented an association between dyslipidemia and breast cancer [21,22]. Increased intake of calories and fat in higher socio-economic group is cited to be the cause of increased estrogen level by the phenomenon of aromatization in adipose tissue which in turn increases the risk of breast cancer [23].…”

Epidermal growth factor receptor expression in urinary bladder cancer

“…Interestingly, similar studies on patients with cancer of different sites from the same geographical location demonstrated different expression patterns of EGFR and HER2 [Table 2]. [2228] Nevertheless, in the current study, neither EGFR nor HER2 did exhibit any correlations with the expression of EGF and IL-6 or presence of HPV-16 [Table 1]. It may be worthwhile to mention that we tried to detect both high risk HPV types 16 and 18, but only 3 cases (10%) were positive for HPV-16 [Figure 3].…”