Status of high level aminoglycoside resistant<i>Enterococcus faecium</i>and<i>Enterococcus faecalis</i>in a rural hospital of central India

Mendiratta, DK; Kaur, Harsimran; Deotale, Vijayshri; Thamke, D; Narang, Rahul; Narang, P

doi:10.4103/0255-0857.43582

Cited by 47 publications

(60 citation statements)

References 9 publications

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“…According to the results of the present study the prevalence of E. faecalis among infectious clinical samples was about 2 fold higher than E. faecium, similar results have been reported from other studies in Iran (Jabalameli et al, 2009;Sharifi et al, 2013), Malaysia (Sharifi et al, 2013), central and south India (Bhat, Paul, & Ananthakrishna, 1998;Fernandes & Dhanashree, 2013;Mendiratta et al, 2008); while in some other studies the prevalence of E. faecium has been reported higher than E. faecalis (Kapoor, Randhawa, & Deb, 2005). Fernandes and Dhanashree (2013) suggested that possessing the hemolysin and gelatinase might be the reason of higher prevalence of E. faecalis in infectious samples (Fernandes & Dhanashree, 2013).…”

Section: Discussionsupporting

confidence: 92%

The Correlation between Resistance to Antimicrobial Agents and Harboring Virulence Factors among Enterococcus Strains Isolated from Clinical Samples

Arbabi¹,

Boustanshenas²,

Rahbar³

et al. 2016

JMBR

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Objectives: In Iran as well as throughout the world Enterococci have been rated as the important cause of urinary tract and nosocomial infections. The aim of this study was to evaluate the relationship between high antimicrobial resistance activity and harboring the virulence factors among clinical Enterococcus isolates. Materials and Methods:Clinical strains were isolated from hospitalized patients. Prevalence of different virulence genes was evaluated by PCR method and the relation between resistance to antibiotics and harboring virulence genes was evaluated by statistical analysis. Results:The results showed that E. faecalis (60%) is more prevalent than E. faecium (26%) and harboring more virulence factors. The highest resistance was related to gentamicin in both E. faecalis and E. faecium isolates with the rate of 88.7% and 93.5% respectively. Harboring esp, ace and cylA are significantly related to resistance to different antibiotics. Conclusion:The antimicrobial resistance and virulence pattern of Enterococcus must be constantly monitored in order to choose the best antimicrobial treat and prevent nosocomial infections. Keywords: antimicrobial resistance, virulence factors, enterococcus, IranHighlights: The E. faecalis is more prevalent than E. faecium among hospitalized patients. The E. faecalis harboring more virulence factors rather than E. faecium. Gentamicin was detected as the most resistance antibiotics among all isolates. The significant correlation between harboring esp, ace and cylA and resistance to antibiotics has been detected.

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Section: Discussionsupporting

confidence: 92%

The Correlation between Resistance to Antimicrobial Agents and Harboring Virulence Factors among Enterococcus Strains Isolated from Clinical Samples

Arbabi¹,

Boustanshenas²,

Rahbar³

et al. 2016

JMBR

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“…Two other studies from Bangladesh reported isolation rates of E. faecalis as 62.5% by Islam and 71.18% by Akhter [14] that were almost similar to our present study [1,14]. The isolation rate of Enterococcus Faecalis from India by Mendiratta et al [15] (85.3%) and Jada & Jayakumar et al…”

Section: Discussionsupporting

confidence: 88%

“…[5] (100%) from Kancheepuram were higher than our present study [5,15]. Reasons could be the predominance of E. fecalis in the endogenous flora of the body [16].…”

Section: Discussioncontrasting

confidence: 62%

Antimicrobial Susceptibility Pattern of Enterococci Isolated from Clinical Specimens at Mymensingh Medical College Hospital, Mymensingh, Bangladesh

Boby¹,

Ahmed²,

Paul³

et al. 2016

JBMOA

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Enterococci are part of the normal intestinal flora of humans and animals but have also emerged as important pathogens responsible for serious infections in hospital and community acquired infections. The aim of this study was to investigate the prevalence of Enterococcus with their antimicrobial susceptibility pattern from patients of Mymensingh Medical College Hospital, Bangladesh during the period from July 2015 to June 2016. Samples were collected and identification of enterococcus was done by standard microbiological procedure and biochemical tests. Multiplex PCR was performed by using species specific primers for Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium), vanA, vanB, vanC1, vanC2/C3 genes for vancomycin resistance. A total of 105 enterococci were isolated from 1201 different clinical specimens (from urine (931), pus (175) and wound swab (95) respectively) from July, 2015 to June, 2016. The prevalence of enterococci was 12.34% in urine, 17.17% in pus and 1.58% in wound samples. Out of 105 enterococci, 80 (77.14%) were Enterococcus faecalis, 1 (0.95%) was E. gallinaram and 24 (22.86%) were other species. All the species were highly resistant to aminoglycosides (Gentamicin) (75.24%) and ciprofloxacin (73.33%). Regarding antibiotic sensitivity, all the enterococci were (100%) sensitive to linezolid and vancomycin followed by nitrofurantoin 93 (88.57%) and imipenem 89 (84.76%). No vancomycin resistant enterococci were identified by disk-diffusion method. But by PCR, vanB was found in 1/80 (1.25%) of the E. faecalis isolates and 01 (100%) of the E. gallinarum. vanC1 was detected in 1 (100%) of E. gallinarum isolates. The vanA and vanC2/C3 gene was not found in any isolates. For the first time, one isolate of E. gallinarum has been found harboring the vanB gene in our hospital. The presence of multidrug resistant enterococci should be considered as danger alarm for serious enterococcal infections and further study in large scale is needed.

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“…Similar result was also observed by Mendiratta et al,2008. High HLGR in E.faecalis and HLSR in E.faecium observed has also been reported (Bhat et al, 1997, Agarwal et al,1999 as also vice versa (Karmarkar et al, 2004).…”

Section: IVsupporting

confidence: 86%

Detection of High Level Aminoglycosides Resistant Entrococci In A Tertiary Care Hospital.

2013

IOSR-JPBS

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Status of high level aminoglycoside resistantEnterococcus faeciumandEnterococcus faecalisin a rural hospital of central India

Cited by 47 publications

References 9 publications

The Correlation between Resistance to Antimicrobial Agents and Harboring Virulence Factors among Enterococcus Strains Isolated from Clinical Samples

The Correlation between Resistance to Antimicrobial Agents and Harboring Virulence Factors among Enterococcus Strains Isolated from Clinical Samples

Antimicrobial Susceptibility Pattern of Enterococci Isolated from Clinical Specimens at Mymensingh Medical College Hospital, Mymensingh, Bangladesh

Detection of High Level Aminoglycosides Resistant Entrococci In A Tertiary Care Hospital.

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