Background
Paraquat has been one of the most widely used herbicides in the world, despite its high human toxicity and the overwhelming evidence of associated high morbidity and mortality. Due to the significant public health implications from paraquat’s use, there have been calls to severely restrict or ban it in many countries. In this paper, we aim to investigate the regulatory status of paraquat on national, regional, and international levels, discuss the successes and challenges of regulatory implementation, and assess the impact of regulation on the incidence of poisonings and deaths.
Methods
We conducted a systematic review of articles on regulations related to the herbicide paraquat. The review concentrated on interventions to mitigate the negative public health impact of paraquat use. We also conducted region-wise and country-wise searches on paraquat regulations to complement our findings. We collected information on paraquat regulations and restrictions, and regulatory aspects of regulation implementation.
Results
At least 74 countries do not authorize paraquat in their markets, with bans, phase-outs, and withdrawals from the market. National and regional bans and phase-outs were effective in reducing paraquat poisonings and deaths. Restrictions on the use and application of paraquat, however, did not always result in a significant reduction in poisoning and suicide mortality, and many countries introduced bans after restrictions proved ineffective.
Conclusion
Our review highlights several elements important for the success of the implementation of regulations, with reductions in harm and no effect on agriculture. It is now time that national, regional, and international authorities pay attention to the scientific evidence of human toxicity and put people’s life and health ahead of economic and business considerations in regulating paraquat. Its use should be replaced by other methods of weed control. This should be a public health priority.