This article is the result of a systematic review of published life cycle assessment (LCA) studies on water and wastewater treatment in Africa. After applying the search and selection criteria, 32 observations for energy use were included and 20 for the global warming potential (GWP) and the eutrophication potential (EP). The dependent variables were categorized by technical, method, and typology factors. The meta‐regression model aligned with the descriptive statistics on the variation of the dependent variables due to water source but not location. Regarding energy use, GWP, and EP, the water source and the study location had the most significant influence in contrast to the life cycle impact assessment method. There is a need for more such LCA studies in Central and Western parts of Africa.