Status of Lipid Profile among the Hypertensive Patients in Bangladesh

Abstract

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled for compare. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Age, waist circumference (WC), body mass index (BMI) showed significant association with hypertensive patients (p<0.001) than in normotensive subjects.The logistic regression analysis indicates hypertensive were 1.2 times higher total cholesterol, 1.3 times higher triglyceride and 1.2 times higher LDL-C than normotensive and was statistically significant (p<0.001). HDL-C was 1.08 times lower in hypertensive than normotensive and statistically significant p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke.University Heart Journal Vol. 10, No. 2, July 2014; 73-77

Pattern of Serum High Density Lipoprotein (Hdl) & Low Density Lipoprotein (Ldl) Level In Hypertensive Patient

“…Table 1 shows that mean age, height, weight, BMI were not statistically significant (p>0.05) between two groups, but mean systolic and diastolic blood pressure were significantly higher in hypertensive group than normotensive group. 13 study the results revealed that the mean value of serum total cholesterol, triglycerides and serum LDL-cholesterol was significantly higher and statistically significant. The mean of HDL of cases were lower than that of controls and was statistically significant.…”

“…DBP showed significant association with hypertensive patients (OR 1.7, 95% CI 0.33-3.29, P<0.05). In another study Forhad et al13 showedbinary logistic regression analysis showed total cholesterol was significantly associated with hypertensive patients Odds Ratio (OR) 1.20; 95% CI (0.97-1.38), p<0.001. Triglyceride and LDL-C was significantly associated with hypertensive patients (OR 1.29; 95% CI 0.91-1.41, p<0.001) and (OR 1.22; 95% CI 0.89-1.31, p<0.001) respectively.…”