Status of Oxidative Stress in Patients With Renal Cell Carcinoma

Ganesamoni, Raguram; Bhattacharyya, Shalmoli; Kumar, Santosh; Chauhan, Ashutosh; Mete, Uttam; Agarwal, Mayank Mohan; Mavuduru, Ravimohan; Kaushik, Gaurav; Mandal, Arup Kumar; Singh, Shrawan Kumar

doi:10.1016/j.juro.2011.11.105

Cited by 32 publications

(38 citation statements)

References 26 publications

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“…Solid tumors endure a severely hypoxic environment, and adaptation to such a hypoxic environment is a critical step in tumor progression. Increases in markers of oxidative stress, such as ROS and nitric oxide, were found in some patients with RCC [39]. In addition, patients with increased parameters of oxidative stress and decreased antioxidant levels were associated with higher grade, stage and metastatic disease [39].…”

Section: Discussionmentioning

confidence: 99%

Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma

Kim

Komiyama

Inomoto

et al. 2016

IJMS

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We analyzed mutations in the mitochondrial ND1 gene to determine their association with clinicopathological parameters and postoperative recurrence of renal cell carcinoma (RCC) in Japanese patients. Among 62 RCC cases for which tumor pathology was confirmed by histopathology, ND1 sequencing revealed the presence of 30 mutation sites in 19 cases. Most mutations were heteroplasmic, with 16 of 19 cases harboring one or more heteroplasmic sites. Additionally, 12 sites had amino acid mutations, which were frequent in 10 of the cases. The 5-year recurrence-free survival (RFS) rate was significantly worse in patients with tumors >40 mm in diameter (p = 0.0091), pathological T (pT) stage ≥3 (p = 0.0122), Fuhrman nuclear atypia grade ≥III (p = 0.0070), and ND1 mutations (p = 0.0006). Multivariate analysis using these factors revealed that mutations in ND1 were significantly associated with the 5-year RFS rate (p = 0.0044). These results suggest a strong correlation between the presence of ND1 mutations in cancer tissue and postoperative recurrence of localized RCC in Japanese patients.

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Section: Discussionmentioning

confidence: 99%

Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma

Kim

Komiyama

Inomoto

et al. 2016

IJMS

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“…In contrast, ROS and NO did not increase in patients with benign tumors when compared to patients with malignant tumors. In patients with metastatic disease who had their tumor surgically removed, ROS production did not decrease and it was associated with the residual disease [6].…”

Section: Introductionmentioning

confidence: 90%

Anti-Angiogenic and Anti-Metastatic Activity of Synthetic Phosphoethanolamine

et al. 2013

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BackgroundRenal cell carcinoma (RCC) is the most common type of kidney cancer, and represents the third most common urological malignancy. Despite the advent of targeted therapies for RCC and the improvement of the lifespan of patients, its cost-effectiveness restricted the therapeutic efficacy. In a recent report, we showed that synthetic phosphoethanolamine (Pho-s) has a broad antitumor activity on a variety of tumor cells and showed potent inhibitor effects on tumor progress in vivo.Methodology/Principal FindingsWe show that murine renal carcinoma (Renca) is more sensitive to Pho-s when compared to normal immortalized rat proximal tubule cells (IRPTC) and human umbilical vein endothelial cells (HUVEC). In vitro anti-angiogenic activity assays show that Pho-s inhibits endothelial cell proliferation, migration and tube formation. In addition, Pho-s has anti-proliferative effects on HUVEC by inducing a cell cycle arrest at the G2/M phase. It causes a decrease in cyclin D1 mRNA, VEGFR1 gene transcription and VEGFR1 receptor expression. Pho-s also induces nuclear fragmentation and affects the organization of the cytoskeleton through the disruption of actin filaments. Additionally, Pho-s induces apoptosis through the mitochondrial pathway. The putative therapeutic potential of Pho-s was validated in a renal carcinoma model, on which our remarkable in vivo results show that Pho-s potentially inhibits lung metastasis in nude mice, with a superior efficacy when compared to Sunitinib.Conclusions/SignificanceTaken together, our findings provide evidence that Pho-s is a compound that potently inhibits lung metastasis, suggesting that it is a promising novel candidate drug for future developments.

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“…In previous study, a decreased activity of total SOD was also observed [9]. Opposite to these results, Ganesamoni et al [10] found the increased activity of SOD in tumour tissue compared to normal kidney tissue.…”

Section: Discussionmentioning

confidence: 81%

The Antioxidant Capacity of the Kidney Tissue in Patients With Renal Cell Carcinoma

Pavlović¹,

Todorović²,

Stojiljković³

et al. 2016

RAD Conference Proceedings

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Abstract. Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.

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Status of Oxidative Stress in Patients With Renal Cell Carcinoma

Abstract: Patients with renal cell carcinoma have increased oxidative stress, which is effectively alleviated by curative resection. In patients with benign tumors antioxidant defense mechanisms maintain normal redox status.

Cited by 32 publications

References 26 publications

Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma

Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma

Anti-Angiogenic and Anti-Metastatic Activity of Synthetic Phosphoethanolamine

The Antioxidant Capacity of the Kidney Tissue in Patients With Renal Cell Carcinoma

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