Status of Serum bilirubin, Serum Proteins and Prothrombin time in babies with Perinatal Asphyxia

Islam, Tariqul; Hoque, Seikh Azimul; Nazir, Fahmida; Bhuiyan, Mostafizur Rahman; Islam, Nazrul

doi:10.3329/jdnmch.v18i2.16022

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…Islam et al, and contradicted by some like the Elsadek et al, study, where they found no significant correlation between serum level of ALP and stages of HIE [9][10][11]. In our study, we have shown that how mortality is increased from lower to higher HIE stages (nil in HIE I to 29.42% in HIE III).…”

contrasting

confidence: 78%

A comparative study of liver function test between normal neonates and neonates with different stages of hypoxic ischemic encephalopathy in a district medical college of Eastern India

et al. 2022

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Background: Hepatic dysfunction is a known complication in neonates with hypoxic ischemic encephalopathy (HIE). Aims and Objectives: We conducted this study to compare hepatic function between normal and asphyxiated newborn and whether the changes in liver function vary with the grade of HIE. Materials and Methods: This observational analytical cross-sectional study was done in a rural medical college of eastern India for 1 year with 51 HIE (17 each in HIE I, II, and III group) and 51 healthy neonates as control. Biochemical parameters of liver function such as alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), total serum bilirubin (TSB), serum albumin, and prothrombin time (PT) were measured in both groups between 48 and 72 h of birth. Results: We found that TSB, liver enzymes, and PT ware significantly elevated and serum albumin reduced in HIE group in comparison to control group. However, TSB, PT, and serum albumin does not differ much among three stages of HIE. By contrast, liver enzymes increases significantly among three stages of HIE, and also, there is significant difference in ALT, AST, and ALP between survivor and non-survivor of HIE babies. Conclusion: Hence, liver function test may serve as an useful early marker of perinatal asphyxia when the history of birth asphyxia is lacking and it can also be used as a prognostic indicator as there is more rise of liver enzymes from low to high grade of HIE and from survived to expired HIE babies.

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contrasting

confidence: 78%

A comparative study of liver function test between normal neonates and neonates with different stages of hypoxic ischemic encephalopathy in a district medical college of Eastern India

et al. 2022

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“…This might be due to the fact that asphyxia is an insult to the newborn due to lack of oxygen, lack of perfusion to various organs which results in multiorgan system dysfunction due to hypoxic damage mainly on brain, lung, liver and intraventricular haemorrhage which affect the bilirubin conjugation ability of the liver that results in jaundice. 41 Also, perinatal asphyxia with hypoxic-ischaemic encephalopathy can lead to disruption of the blood-brain barrier, thereby allowing free entry of the unconjugated bilirubin to the neurons resulting in acute bilirubin encephalopathy. Besides, kidney damage from PNA can lead to less excretion of the conjugated bilirubin, thereby causing conjugated hyperbilirubinaemia and jaundice.…”

Section: Discussionmentioning

confidence: 99%

Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

Demis

Alemnew

Getie

et al. 2020

bmjpo

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BackgroundNeonatal jaundice is associated with a significant risk of neonatal morbidity and mortality. It is a major cause of hospital neonatal intensive care unit admission and readmissions during the neonatal period. Hence, the study aimed to identify the determinant factors of neonatal jaundice among neonates admitted at five referral hospitals in Amhara region, Northern Ethiopia.MethodA hospital-based unmatched case-control study design was employed, on 447 neonates (149 cases and 298 controls) at referral hospitals in Amhara region, Northern Ethiopia, from 1 March to 30 July 2019. Consecutive sampling method was used to select both the cases and controls. The collected data were entered into Epi data V.4.2 and then exported into SPSS window V.24 for analysis. Bivariable and multivariable analysis were carried out by using binary logistic regression. A p value of <0.05 was considered as significant difference between cases and controls for the exposure variable of interest.ResultsThe median (±IQR) age of neonate at the time of admission and gestational age were 3±2 days and 38 (±3) weeks, respectively. Prolonged duration of labour (adjusted OR (AOR)=2.45, 95% CI 1.34 to 4.47), being male sex (AOR=3.54, 95% CI 1.99 to 6.29), low birth weight (AOR=5.06, 95% CI 2.61 to 9.82), birth asphyxia (AOR=2.88, 95% CI 1.38 to 5.99), sepsis (AOR=2.49, 95% CI 1.22 to 5.11) and hypothermia (AOR=2.88, 95% CI 2.63 to 14.02) were the determinant factors for neonatal jaundice.ConclusionsProlonged duration of labour, hypothermia, sepsis, birth asphyxia, low birth weight and sex of neonate were independent determinants of neonatal jaundice. Early recognition and management of identified modifiable determinants are the recommended interventions.

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“…Ethiopia [48] supported that neonatal jaundice is in uenced by birth asphyxia. This similarity in nding was because perinatal asphyxia remains a common problem in the neonatal nursery and is a signi cant coincidence with neonatal hyperbilirubinemia in neonatal intensive care and it was also an insult to the newborn due to lack of oxygen, lack of perfusion to various organs which ends up in multi-organ system dysfunction due to hypoxic damage principally on brain, lung, liver and intraventricular hemorrhage that affect bilirubin conjugation ability of the liver that leads to jaundice [49]. Also, perinatal asphyxia with the hypoxic-ischemic neurological disorder will disrupt the blood-brain barrier, thereby permitting free entry of the unconjugated bilirubin to the neurons leading to a neurological disorder.…”

Section: Discussionmentioning

confidence: 99%

Hyperbilirubinemia and associated factors among neonates admitted to neonatal care unit in Jimma Medical Center

Asaye¹,

Bekele²,

Getachew³

et al. 2022

Preprint

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Background: Neonatal hyperbilirubinemia is a widespread and significant clinical problem among neonates worldwide. Globally, every year about 1.1 million babies develop it and the vast majority reside in South Asia and sub-Saharan Africa. Studies on magnitude and factors associated with neonatal hyperbilirubinemia are limited in Ethiopia. So this study was aimed at assessing the prevalence and associated factors of neonatal hyperbilirubinemia among hospitalized neonates in the neonatal intensive care unit of Jimma Medical Center (JMC), Jimma, South West Ethiopia. Methods: Hospital-based cross-sectional study was conducted at JMC from July 24 to October 19, 2020. A total of two hundred twenty-two neonates with their mothers were included and conveniently selected. Data was collected by interviewing mothers through structured questionnaires and reviewing neonates' medical records using a checklist. Multivariable binary logistic regression analyses were employed to identify factors associated with neonatal hyperbilirubinemia. Results: from a total of neo-maternal pairs included in the studies; the proportion of Neonatal hyperbilirubinemia was found to be 94(42.3%). Neo-maternal ABO incompatibility 33 (35.1%), prematurity41 (43.6%), sepsis 35 (37.2%), Neonatal birth asphyxia 20 (21.2%), and Rh isoimmunization 10 (10.6%) was significantly associated with neonatal hyperbilirubinemia.Conclusion and Recommendations: The prevalence of neonatal hyperbilirubinemia in the study setting was high. Antenatal care (including both mother and fetus detail examination and follow-ups) as well cautions during labor need to focus since Neonatal hyperbilirubinemia-associated factors were maternal and neonatal. Hence, further assessment, early intervention, and timely treatment are important to mitigate the burdens in neonates due to hyperbilirubinemia.

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Status of Serum bilirubin, Serum Proteins and Prothrombin time in babies with Perinatal Asphyxia

Cited by 5 publications

References 8 publications

A comparative study of liver function test between normal neonates and neonates with different stages of hypoxic ischemic encephalopathy in a district medical college of Eastern India

A comparative study of liver function test between normal neonates and neonates with different stages of hypoxic ischemic encephalopathy in a district medical college of Eastern India

Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

Hyperbilirubinemia and associated factors among neonates admitted to neonatal care unit in Jimma Medical Center

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