2022
DOI: 10.3390/cancers14051180
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Status of the Current Treatment Options and Potential Future Targets in Uterine Leiomyosarcoma: A Review

Abstract: Uterine leiomyosarcoma (uLMS) is the most common subtype of mesenchymal tumors in the uterus. This review aims to summarize the current standard therapies and the molecular properties of uLMS for novel molecular-targeted therapies. Although 65% of uLMS cases are diagnosed in stage I, the 5-year overall survival rate is less than 60%. The only effective treatment for uLMS is complete and early resection, and chemotherapy is the main treatment for unresectable advanced or recurrent cases. No chemotherapy regimen… Show more

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Cited by 14 publications
(15 citation statements)
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“…Preservation of the ovaries could be considered in premenopausal patients to preserve hormonal function, especially in stages I and II of the disease [ 20 ]. Adjuvant radiotherapy is ineffective, and there is no established therapeutic regimen for adjuvant chemotherapy [ 41 ]. The standard treatment for resectable cases is total hysterectomy with bilateral abdominal adnexectomy, and for unresectable, advanced, or recurrent cases, the therapeutic option is chemotherapy [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Preservation of the ovaries could be considered in premenopausal patients to preserve hormonal function, especially in stages I and II of the disease [ 20 ]. Adjuvant radiotherapy is ineffective, and there is no established therapeutic regimen for adjuvant chemotherapy [ 41 ]. The standard treatment for resectable cases is total hysterectomy with bilateral abdominal adnexectomy, and for unresectable, advanced, or recurrent cases, the therapeutic option is chemotherapy [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Adjuvant radiotherapy is ineffective, and there is no established therapeutic regimen for adjuvant chemotherapy [ 41 ]. The standard treatment for resectable cases is total hysterectomy with bilateral abdominal adnexectomy, and for unresectable, advanced, or recurrent cases, the therapeutic option is chemotherapy [ 41 ]. In our study, the initial therapeutic behavior was represented by laparotomic total hysterectomy in most cases, with only two cases being surgically treated by total hysterectomy with bilateral adnexectomy and subtotal hysterectomy, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…This conclusion was in accordance with both ESMO and NCCN guidelines, both of which concluded RT is not recommended for stage I uLMS and should be discussed with patients in cases with higher stages considering special risk factors, such as mitotic count, age and tumor necrosis ( 26 , 27 ). Based on the limited literature, in the advanced stage that is incompletely removed or metastatic disease, radiotherapy is persistently valuable when used in palliative treatment to distant locations ( 15 ), although adjuvant systemic chemotherapy is usually administered for unresectable advanced or recurrent disease ( 28 ).…”
Section: Discussionmentioning
confidence: 99%
“…incompletely removed or metastatic disease, radiotherapy is persistently valuable when used in palliative treatment to distant locations (15), although adjuvant systemic chemotherapy is usually administered for unresectable advanced or recurrent disease (28).…”
Section: Discussionmentioning
confidence: 99%
“…Они сопро вождаются интенсивным поглощением ФДГ, однако сильно вариабельное поглощение ФДГ в лейомиомах затрудняет дифференциацию [13]. Лейомиосаркома является наиболее частой саркомой матки, но встречается только в 1% всех гинеко логических злокачественных новообразований [17]. Она часто визуализируется как большая гетерогенная масса с внутренними участками некроза, может напоминать дегенеративную лейомиому матки, как с участками некроза, так и с интенсивным поглощением ФДГ.…”
Section: маткаunclassified