Status of the Gastric Mucosa with Endoscopically Diagnosed Gastrointestinal Stromal Tumor

Abstract

Background. Since gastrointestinal stromal tumor (GIST) is a mesenchymal submucosal tumor, the endosonographic, CT, and MRI features of gastric GISTs have been widely investigated. However, the GIST-bearing gastric mucosa status has not been reported. Objective. To characterize the GIST-bearing gastric mucosa status in terms of the degree of inflammation and atrophy, assessed endoscopically. Subjects and Methods. The subjects were 46 patients with submucosal tumors (histologically proven gastric GISTs) who had undergone upper gastrointestinal endoscopy in our hospital between April 2007 and September 2012. They were retrospectively evaluated regarding clinicopathological features, the endoscopically determined status of the entire gastric mucosa (presence or absence and degree of atrophy), presence or absence and severity of endoscopic gastritis/atrophy (A-B classification) at the GIST site, and presence or absence of H. pylori infection. Results. Twenty-three patients had no mucosal atrophy, but 17 and 6 had closed- and open-type atrophy, respectively. Twenty-six, 5, 12, 1, 1, and 1 patients had grades B0, B1, B2, B3, A0, and A1 gastritis/atrophy at the lesion site, respectively, with no grade A2 gastritis/atrophy. Conclusion. The results suggest that gastric GISTs tend to arise in the stomach wall with H. pylori-negative, nonatrophic mucosa or H. pylori-positive, mildly atrophic mucosa.

Risk Factors for Mucosal Ulceration in Gastric Gastrointestinal Stromal Tumors (GIST)

“…However, no such association was noted in univariate analysis. Consistent with our results, Nonaka, et al also reported, in 46 patients with gastric GISTs, that the most common mucosal characteristics are non-atrophic, H. pylori negative or mild-atrophic H. pylori positive gastritis [28]. This study demonstrated that the gastric mucosa lying above the GISTs is usually relatively healthy.…”

Transient Receptor Potential Ankyrin 1 and Substance P Mediate the Development of Gastric Mucosal Lesions in a Water Immersion Restraint Stress Rat Model

“…AGML remains an important clinical problem because many people are affected by this condition, which may also cause gastrointestinal bleeding [1, 5]. Previous results have shown that gastric mocosal lesions are associated with gastrointestinal stromal tumors and gastric cancer whose diagnosis, tumor progression, and treatment remain need further investigation [6-9]. Thus, it is urgent to identify novel mediators and the signaling pathways involved in the pathogenesis of AGML, which will provide new potential targets for treatment.…”