Status of vitamins A and E in schoolchildren in the centre west of Tunisia: a population-based study

Fares, Samira; Chahed, Mohamed Kouni; Feki, Moncef; Béji, C.; Traissac, Pierre; Ati, Jalila El; Kaabachi, Naziha

doi:10.1017/s1368980010001631

Cited by 20 publications

(14 citation statements)

References 26 publications

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“…A lower vitamin E serum level is positively associated with RRTIs in children, thereby indicating that sufficient vitamin E intake may help prevent the induction of RRTIs in children. The cut-off value suggested that a vitamin E serum level lower than 7.85 mg/L may be a risk factor for RRTIs, whereas vitamin E serum levels higher than the normal value (7 mg/mL) [35, 36] may prevent RRTIs in children.…”

Section: Discussionmentioning

confidence: 99%

Low Serum Levels of Vitamins A, D, and E Are Associated with Recurrent Respiratory Tract Infections in Children Living in Northern China: A Case Control Study

Zhang¹,

Ding²,

Li³

et al. 2016

PLoS ONE

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BackgroundThis study aimed to investigate the association of serum concentrations of vitamin A, D, and E with recurrent respiratory tract infections (RRTIs).MethodsA total of 1200 children aged at 0.5–14 years were selected via a face-to-face survey in Harbin, China. Among the participants, 600 children with RRTIs comprised the symptomatic group (RRTI group), whereas 600 healthy children were used as controls (control group). Blood samples were collected to measure serum levels of vitamins A and E by HPLC; the serum level of 25-hydroxycholecalciferol (25(OH)D), was measured by HPLC-MS/MS.ResultsSerum levels of vitamins A and E, as well as 25(OH)D, were significantly lower in the RRTI group than the control group. The conditional logistic regression model and the receiver-operating characteristic curve showed that the insufficiency or deficiency of vitamins A, D, and E was positively correlated with RRTI occurrence (p < 0.05).ConclusionsLow serum concentrations of vitamins A, D, and E were associated with RRTIs in children from northern China.

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Section: Discussionmentioning

confidence: 99%

Low Serum Levels of Vitamins A, D, and E Are Associated with Recurrent Respiratory Tract Infections in Children Living in Northern China: A Case Control Study

Zhang¹,

Ding²,

Li³

et al. 2016

PLoS ONE

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“…Vitamin A deficiency was considered with retinol concentrations <10 μg/dL and low concentrations <20 μg/dL [23]. Vitamin E deficiency was defined with a concentration of alpha-tocopherol <3 μg/mL and low concentrations <5 μg/mL [24]. When using the vitamin E:lipids ratio, vitamin E deficiency was considered with <0.8 mg/g [25].…”

Section: Methodsmentioning

confidence: 99%

Zinc, Iron and Vitamins A, C and E Are Associated with Obesity, Inflammation, Lipid Profile and Insulin Resistance in Mexican School-Aged Children

et al. 2013

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The objective of this cross-sectional study was to evaluate the relationship between micronutrient status and obesity, lipids, insulin resistance and chronic inflammation in children. Weight, height, waist circumference and body composition (dual-energy X-ray absorptiometry (DEXA)) were determined in 197 school-aged children. Lipids, glucose, insulin, C-reactive protein (CRP), zinc, iron and vitamins A, C and E were analyzed in blood. Vitamin C and vitamin E:lipids were negatively associated with Body Mass Index (BMI), waist-to-height ratio (WHR) and body and abdominal fat (p < 0.05). Vitamin A was positively associated with BMI, BMI-for-age, WHR and abdominal fat (p < 0.05). Iron and vitamin E:lipids were negatively associated with insulin (p < 0.05). Vitamins A, C and E and iron were negatively associated with CRP (p < 0.05). Interaction analysis showed that children who were overweight and obese who also had low concentrations of vitamin A had higher CRP and lower triglycerides (p < 0.1), children with low vitamin E had significantly lower glucose and triglycerides (p < 0.1) and higher low-density lipoprotein (LDL) concentrations (p < 0.05), and children with low zinc concentrations had higher insulin resistance compared with children with adequate weight (p < 0.05). In conclusion, low vitamin C concentration and vitamin E:lipids were associated with obesity. Furthermore, low concentrations of zinc, vitamins A and E in children who were overweight and obese were associated with lipids, inflammation and insulin resistance.

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“…In a survey of the U.S. population, 26–41% of individuals (depending on ethnicity) had blood plasma αT concentrations at levels that were associated with an increased risk for cardiovascular disease (Ford and Sowell 1999). Although studies of vitamin E sufficiency in developing countries are less widespread and comprehensive, it has been reported that dietary intake and plasma levels of αT were even lower than that in developed countries (Fares et al 2011; Monteiro et al 2009; Oldewage-Theron et al 2010). Given the substantial variation for grain levels of tocopherols (Chander et al 2008; Li et al 2012; Wong et al 2003) and tocotrienols (Weber 1987) among diverse maize lines, it should be possible to exploit this genetic diversity in marker-assisted selection programs that target specific endogenous tocochromanols in maize grain.…”

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confidence: 99%

Genome-Wide Association Study and Pathway-Level Analysis of Tocochromanol Levels in Maize Grain

Lipka

Gore

Magallanes‐Lundback

et al. 2013

G3 Genes|Genomes|Genetics

167

231

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Tocopherols and tocotrienols, collectively known as tocochromanols, are the major lipid-soluble antioxidants in maize (Zea mays L.) grain. Given that individual tocochromanols differ in their degree of vitamin E activity, variation for tocochromanol composition and content in grain from among diverse maize inbred lines has important nutritional and health implications for enhancing the vitamin E and antioxidant contents of maize-derived foods through plant breeding. Toward this end, we conducted a genome-wide association study of six tocochromanol compounds and 14 of their sums, ratios, and proportions with a 281 maize inbred association panel that was genotyped for 591,822 SNP markers. In addition to providing further insight into the association between ZmVTE4 (γ-tocopherol methyltransferase) haplotypes and α-tocopherol content, we also detected a novel association between ZmVTE1 (tocopherol cyclase) and tocotrienol composition. In a pathway-level analysis, we assessed the genetic contribution of 60 a priori candidate genes encoding the core tocochromanol pathway (VTE genes) and reactions for pathways supplying the isoprenoid tail and aromatic head group of tocochromanols. This analysis identified two additional genes, ZmHGGT1 (homogentisate geranylgeranyltransferase) and one prephenate dehydratase parolog (of four in the genome) that also modestly contribute to tocotrienol variation in the panel. Collectively, our results provide the most favorable ZmVTE4 haplotype and suggest three new gene targets for increasing vitamin E and antioxidant levels through marker-assisted selection.

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Status of vitamins A and E in schoolchildren in the centre west of Tunisia: a population-based study

Cited by 20 publications

References 26 publications

Low Serum Levels of Vitamins A, D, and E Are Associated with Recurrent Respiratory Tract Infections in Children Living in Northern China: A Case Control Study

Low Serum Levels of Vitamins A, D, and E Are Associated with Recurrent Respiratory Tract Infections in Children Living in Northern China: A Case Control Study

Zinc, Iron and Vitamins A, C and E Are Associated with Obesity, Inflammation, Lipid Profile and Insulin Resistance in Mexican School-Aged Children

Genome-Wide Association Study and Pathway-Level Analysis of Tocochromanol Levels in Maize Grain

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