Status updates of Newcastle disease and amelioration effects of medicinal plants against Newcastle disease virus: A review

Ashraf, Asma; Mahboob, Soltanali; Andleeb, Rahat; Ijaz, Muhammad Umar; Shah, Muhammad Arif

doi:10.4149/av_2018_101

Cited by 8 publications

(6 citation statements)

References 55 publications

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“…On an initial rigorous, or strict, analysis, removing all potential contaminating human, bacterial or phage sequences, RNA virus sequences in the paramyxovirus ( 28 ) and orthomyxovirus ( 29 ) families were detected. Virus sequence detection was read blinded by four investigators (ST, SS-C, AV, AL).…”

Section: Resultsmentioning

confidence: 99%

“…Both paramyxovirus and orthomyxovirus families have been reported as causes for myocarditis in patients without known prior cancer or chemotherapy. The detectable sequences for orthomyxovirus matched to influenza A ( 29 ) and those for paramyxovirus with avulavirus ( 28 ). On a secondary broad analysis using a customized screen, we were able to detect larger numbers of RNA virus sequences for orthomyxovirus influenza A and paramyxovirus Avulavirus, as well as a larger array of RNA viruses including retroviruses, insect viruses and phage.…”

Section: Discussionmentioning

confidence: 99%

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RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

Varkoly

Tan

Beladi

et al. 2022

Front. Cardiovasc. Med.

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BackgroundViral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.ObjectiveAn unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function.MethodsHigh-throughput sequencing of RNA isolated from blood samples was analyzed following chemotherapy for hematological malignancies (N = 28) and compared with left ventricular ejection fraction (LVEF).ResultsOn initial rigorous analysis, low levels of influenza orthomyxovirus and avian paramyxovirus sequences were detectable, but without significant correlation to LVEF (r = 0.208). A secondary broad data mining analysis for virus sequences, without filtering human sequences, detected significant correlations for paramyxovirus with LVEF after chemotherapy (r = 0.592, P < 0.0096). Correlations were similar for LVEF pre- and post- chemotherapy for orthomyxovirus (R = 0.483, P < 0.0421). Retrovirus detection also correlated with LVEF post (r = 0.453, p < 0.0591), but not pre-chemotherapy, but is suspect due to potential host contamination. Detectable phage and anellovirus had no correlation. Combined sequence reads (all viruses) demonstrated significant correlation (r = 0.621, P < 0.0078). Reduced LVEF was not associated with chemotherapy (P = NS).ConclusionsThis is the first report of RNA virus screening in circulating blood and association with changes in cardiac function among patients post chemotherapy, using unbiased, blinded, high-throughput sequencing. Influenza orthomyxovirus, avian paramyxovirus and retrovirus sequences were detectable in patients with reduced LVEF. Further analysis for RNA virus infections in patients with cardiomyopathy after chemotherapy is warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

Varkoly

Tan

Beladi

et al. 2022

Front. Cardiovasc. Med.

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“…Some of the plant species identified in the present study have been reported in previous studies with scientific evidence of their use in poultry. The extracts of these plants, including Acacia nilotica, Withania somnifera, and Azadiractha indica have biological activities against Escherichia coli, Staphyllococcus aureus, Klebsiella pneumoniae and against Newcastle disease and fowl pox viruses (Mohamed et al, 2010;Ashraf et al, 2018). They also act on external parasites and helminths (Carine et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Characterization and Typology of Traditional Poultry Farming Systems in Southern Niger

Moustapha¹,

Adamou²,

Talaki³

2022

jwpr

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An appropriate agricultural policy that integrates knowledge of endogenous poultry practices should enhance household resilience by contributing to food and nutrition security and sustainable development in developing countries. The current cross-sectional survey aimed to characterize poultry breeding systems and identify types of traditional poultry farmers in Maradi and Zinder in southern Niger. Therefore, 600 households were investigated for the socio-economic parameters of poultry farmers, the breeding methods, the zootechnical parameters of the local chicken, and the health parameters relating to biosecurity and animal care. The results of the descriptive analyses indicated that traditional poultry activity is mainly carried out by men (73.5%) and small farmers (74.2%). Breeding management was primarily free-range breeding (99.3%). The majority of the surveyed herders (67.8%) were illiterate. However, 41.5% of them attended traditional Islamic Koranic schools. Most farmers (80%) were small-scale livestock farmers with an average herd size of 22 ± 24.9. The poultry raised were 93.3% local breeds, with chicken domination (66%). The housing did not meet the required standards, and the feed was mainly cereals. The female chicken can potentially produce 12.64 fertile eggs per clutch and brood 3.53 times per year. The leading cause of mortality in poultry was avian diseases (93.7%) and Newcastle disease in some cases. Poultry vaccination against Newcastle disease was reported by 31.5% of respondents. Of the respondents, 20% have partially observed hygiene and biosecurity measures. About 35.5% of the participants reported the provision of veterinary care, while 44% used phytotherapy to prevent or treat poultry diseases. Based on the results of this cluster analysis, three classes of poultry farmers were distinguished, each with specific characteristics. Poultry farmers in class 1 were particularly characterized by the diversity of their main activity and their level of education, those in class 2 were mostly employed in agriculture and had little school experience, and those in class 3 were characterized by their low level of vaccination practice and their lack of therapeutic animal care. The results also indicated that 15.7%, 70.8%, and 13.5% of poultry farmers belonged to classes 1, 2, and 3, respectively. Keywords: Characterization, Farmer, Niger, Poultry diseases, Poultry production

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“…Medicinal plants produce bioactive compounds which are responsible for their therapeutical potentials (Barbieri et al, 2017;Credo et al, 2018). Several medicinal plants have been scientifically confirmed to have anti-NDV activity (Lagu & Kayanja, 2010;Sulaiman et al, 2011;Bakari et al, 2012;Raza et al, 2015;Al-Hadid, 2016;Ashraf et al, 2018;Doostmohammadian et al, 2020;Shahzad et al, 2020) though their bioactive compounds responsible for it, are not mentioned.…”

Section: Introductionmentioning

confidence: 99%

Anti-Newcastle Disease Virus activity of 3β and 3α Friedelanol Triterpenoids from the leaves of Synadenium glaucescens Pax

Credo¹

2022

Trop Biomed

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Newcastle Disease (ND) is a highly pathogenic disease of avian species which is caused by Newcastle Disease Virus (NDV). It is one of the major causes of mortality and morbidity to poultry industry in the third world countries. Currently, there is no treatment measures against ND; the only existing measure is vaccination, though it is incapable to offer 100% immunity. In Tanzania, the leaves of Synadenium glaucescens Pax. are traditionally used for treatment of various ailments including ND. Previously, its leaves extract has been scientifically confirmed to exhibit anti-NDV activity though bioactive compound(s) responsible for this activity is/are unknown. Therefore, this study was aimed to evaluate anti-NDV activity of 3β-Friedelanol (1) and 3α-friedelanol (2) isolated from its leaves extract. Isolation of these compounds was achieved by column chromatography method whereas, their chemical structures were determined by Nuclear Magnetic Resonance (NMR) data and by comparing with the available literature NMR data. Anti-NDV activity study was done in embryonated chicken eggs (ECEs). Treatment of NDV inoculated ECEs with 3β-Friedelanol (1) reduced the viral load to zero and maintained the survival of embryos, this was revealed by continuous organs formation and increase in embryo weights with no significant different (p > 0.05) from un-inoculated ECE. These effects suggest that, 3β-Friedelanol (1) possesses anti-NDV activity. Therefore, existence of 3β-Friedelanol (1) in the leaves of S. glaucescens may justify its earlier described anti-NDV activity and traditional use in the treatment of ND. Hence, its leaves extract may be considered for development of anti-NDV herbal formulation while 3β-Friedelanol could either serve as a drug or lead compound for synthesis of anti-NDV drugs.

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Status updates of Newcastle disease and amelioration effects of medicinal plants against Newcastle disease virus: A review

Cited by 8 publications

References 55 publications

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

Characterization and Typology of Traditional Poultry Farming Systems in Southern Niger

Anti-Newcastle Disease Virus activity of 3β and 3α Friedelanol Triterpenoids from the leaves of Synadenium glaucescens Pax

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