Statutory Imposed Terms of Stress, Distress, Well-Being and Animal Welfare: Suggested Guidelines for Humane Endpoints in Animal Studies

Gauvin, David V.

doi:10.24218/vjpps.2018.21

Cited by 2 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highly disadvantageous net effects of the internal factors cannot be compensated anymore with even the most advantageous net effects of the external factors, and the animal will suffer from seriously impaired welfare. Also, this case should prompt those in charge of safeguarding animal welfare to think about, and eventually apply, a humane endpoint (Gauvin et al, 2018).…”

Section: The Dynamic Component In Dawconmentioning

confidence: 99%

A dynamic concept of animal welfare: The role of appetitive and adverse internal and external factors and the animal’s ability to adapt to them

2022

View full text Add to dashboard Cite

Animal welfare is a multifaceted issue that can be approached from different viewpoints, depending on human interests, ethical assumptions, and culture. To properly assess, safeguard and promote animal welfare, concepts are needed to serve as guidelines in any context the animal is kept in. Several different welfare concepts have been developed during the last half decade. The Five Freedoms concept has provided the basis for developing animal welfare assessment to date, and the Five Domains concept has guided those responsible for safeguarding animal welfare, while the Quality of Life concept focuses on how the individual perceives its own welfare state. This study proposes a modified and extended version of an earlier animal welfare concept - the Dynamic Animal Welfare Concept (DAWCon). Based on the adaptability of the animal, and taking the importance of positive emotional states and the dynamic nature of animal welfare into account, an individual animal is likely in a positive welfare state when it is mentally and physically capable and possesses the ability and opportunity to react adequately to sporadic or lasting appetitive and adverse internal and external stimuli, events, and conditions. Adequate reactions are elements of an animal’s normal behavior. They allow the animal to cope with and adapt to the demands of the (prevailing) environmental circumstances, enabling it to reach a state that it perceives as positive, i.e., that evokes positive emotions. This paper describes the role of internal as well as external factors in influencing welfare, each of which exerts their effects in a sporadic or lasting manner. Behavior is highlighted as a crucial read-out parameter. As most animals under human care are selected for certain traits that may affect their behavioral repertoire it is crucial to have thorough ethograms, i.e., a catalogue of specific behaviors of the species/strain/breed under study. DAWCon highlights aspects that need to be addressed when assessing welfare and may stimulate future research questions.

show abstract

Section: The Dynamic Component In Dawconmentioning

confidence: 99%

A dynamic concept of animal welfare: The role of appetitive and adverse internal and external factors and the animal’s ability to adapt to them

2022

View full text Add to dashboard Cite

show abstract

“…The International Association for the Study of Pain defined «the pain» as an unpleasant sensory experience along with actual or potential tissue damage. Based on this definition, pain is always subjective (Gauvin et al, 2018).…”

Section: Historical Background Of the Use Of Animals In Biomedical Research And The Guidelines Governing Itmentioning

confidence: 99%

“…Nowadays, researchers have shown that animal suffering leads to the extensive change of biomarkers in the animal body, affecting data obtained from the experiment (Gauvin et al, 2018). Since the results of research are evaluated based on the decreased suffering in the animal, new methods including pre-clinical and non-clinical procedures were introduced for HEP.…”

Section: Ethics In the Implementation Of Humane Endpointsmentioning

confidence: 99%

Volume 25, Issue 1 (March 2021) Physiol Pharmacol 2021, 25(1): 1-6 | Back to browse issues page 10.32598/ppj.25.1.10 XML Print Download citation: BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks Send citation to: Mendeley Zotero RefWorks Najafi H, Zarei R, Alimoradian A, Asafari M, Mohammadi M, Samadi F, et al . A review on humane endpoints in animal experimentation for biomedical research. Physiol Pharmacol. 2021; 25 (1) :1-6 URL: http://ppj.phypha.ir/artic

et al. 2020

View full text Add to dashboard Cite

Introduction: The use of animals in experiments and their role in the development of medical sciences are undeniable. Humane endpoints terminate pain and distress in laboratory animals, which are experimented in painful procedures and an involuntary manner. This study was going to review studies published in this area to assist researchers in developing their approach. Methods: Articles used in this review study were obtained from relevant databases including Pubmed, Scopus, Science Direct, OVID, SID, Magiran and Google scholar. Results: “Humane endpoints” or killing the animal humanely means the point at which an experimental animal’s pain and/or distress is terminated. This pain and distress are not necessarily accompanied by clinical symptoms and it can also be recognized by biochemical, physiological and molecular biomarkers testing. Conclusion: Regarding the extensive use of laboratory animals, the aim is not only to take care of animals but also to develop knowledge and prevent unintentional animal suffering and death. Increasing awareness of ethical issues regarding research animal use needs scientific information and designing experiments, which are terminated immediately after achieving main goals. Otherwise, it threatens the life of animal and leads to the animal suffering.

show abstract

Statutory Imposed Terms of Stress, Distress, Well-Being and Animal Welfare: Suggested Guidelines for Humane Endpoints in Animal Studies

Abstract: Bad terminology is the enemy of good science.

Cited by 2 publications

References 24 publications

A dynamic concept of animal welfare: The role of appetitive and adverse internal and external factors and the animal’s ability to adapt to them

A dynamic concept of animal welfare: The role of appetitive and adverse internal and external factors and the animal’s ability to adapt to them

Contact Info

Product

Resources

About