Stavudine, Didanosine, and Zalcitabine

Skowron, Gail; Chowdhry, Sapna; Stevens, Michael R.

doi:10.1007/978-1-59745-085-0_3

Cited by 4 publications

(1 citation statement)

References 168 publications

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“…Zidovudine: Zidovudine (azidothymidine: AZT) was the first nucleoside reverse transcriptase inhibitor (NRTI) to be developed and commercialized in 1987 for the treatment of symptomatic individuals infected with HIV or AIDS, and the next three compounds were didanosine in 1991, zalcitabine in 1992 and stavudine in 1994 [92][93][94][95]. Today, monotherapy with zidovudine is uncommon because HAART has proved a formidable clinical combination, which usually includes two NRTI drugs and HIV-1 protease inhibitor [96].…”

Section: Antiretroviral Drugsmentioning

confidence: 99%

Drugs-related cardiomyopathy: A systematic review and pooled analysis of pathophysiology, diagnosis and clinical management

Albakri¹

2019

Int Med Care

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Drug-induced cardiomyopathy (CM) is a potentially reversible form of acquired CM and a common consequence of exposure to numerous medically prescribed drugs. It is particularly a common serious adverse side effect of anticancer and antiretroviral therapies. The two drugs may have significantly improved longevity in cancer and HIV-infected patients respectively but their cardiotoxic effects threaten to undermine their therapeutic efficacy and reduce survival in affected patients. Hospitalization due to drug-induced CM also places a considerable burden on the healthcare system in terms of reduced drug efficacy and patient management. Early detection is clinically important for improve efficacy in the management of drug-induced CM as well as the prevention of the progression into heart failure. Thus, prescribers should be fully aware of drugs with the potential to cause CM and the clinical value of monitoring the cardiotoxic effects of these drugs. Thus, the present paper provides a systematic review of literature and meta-analysis of diagnosis and management methods. The aim is to broaden the understanding of the major causative drugs, pathophysiology, diagnosis and management of drug-induced CM.

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Section: Antiretroviral Drugsmentioning

confidence: 99%