Stavudine Induced Acute Pancreatitis in Paediatric Human Immunodeficiency Virus Infection

Stavudine induced acute necrotizing pancreatitis with tetany in a pediatric patient

“…The risk of AP in HIV-infected populations is 35 to 800 times higher than in the general population. [ 2 ] The risk increases with the progression of HIV infection and worsening of CD4 count. A retrospective cohort study of 10 years duration from United States of America observed that female gender, use of stavudine and aerosolized pentamidine, CD4 count less than 50 cells/cm 3 are significantly associated with pancreatitis in HIV positive patients.…”

“…[4] Few cases of stavudine induced pancreatitis have been reported from India. [12] Here, we report a rare case of acute necrotizing pancreatitis associated with tetany, which was probably due to stavudine.…”

“…Among them, antiretroviral therapy (ART) is rarely associated with this complication with stavudine, didanosine and lamivudine being the most common causative agents. [ 1 2 ] Incidence of developing AP is higher in human immunodeficiency virus (HIV) patients than the general population. [ 3 ] Necrotizing pancreatitis (NP) is a severe form of acute pancreatitis which has a higher incidence of multi-organ failure.…”