Stavudine, lamivudine and indinavir in drug abusing and non-drug abusing HIV-infected patients: Adherence, side effects and efficacy

Roca, Bernardino; Gómez, Cayetano J.; Arnedo, Alberto

doi:10.1016/s0163-4453(99)90006-3

Cited by 44 publications

(29 citation statements)

References 21 publications

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“…46 9 10 6 /l versus 80 9 10 6 /l (P = 0.82) Roca et al (1999) Virological efficacy was reached in [40% of patients of both groups in all visits (IDU and non-IDUS)…”

Section: Discussionmentioning

confidence: 92%

“…Six studies used a combination of adherence measurements, e.g., self-report and MEMS (Crystal et al 2001;Kerr et al 2005;Lucas et al 2001;Martini et al 2004;McNabb et al 2001;Roca et al 1999). …”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eighteen of the 38 studies evaluated HAART-related clinical outcomes (Avants et al 2001;Bouhnik et al 2005;Carrieri et al 2003a;Duran et al 2001;Knowlton et al 2006;Lucas et al 2001;McNabb et al 2001;Moatti et al 2000;Palepu et al 2003aPalepu et al , b, 2004aPalepu et al , b, 2006Pradier et al 2001;Roca et al 1999;Waldrop-Valverde et al 2006;Wood et al 2003aWood et al , 2004b (Table 3).…”

Section: Treatment Outcomesmentioning

confidence: 99%

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Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

et al. 2008

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We conducted a meta-analysis of studies assessing adherence to highly active antiretroviral therapy (HAART) and a qualitative systematic review of factors associated with better HAART outcomes among HIV+ drug users (DU). Thirty-eight studies were considered, which analyzed 14,960 patients (11,394 HIV+ DU, 76.2%). Overall adherence (pooled percent of DU classified as adherent in each study) was 0.60 (95% CI: 0.52-0.68), similar to levels identified by studies conducted with HIV+ patients who are not drug users. Time frame used to measure adherence was an independent predictor of inter-study heterogeneity. The systematic review identified better HAART outcomes among former DU, those with less severe psychiatric conditions, those receiving opioid substitution therapy and/or psychosocial support. Patients initiating HAART with lower viral load and higher CD4 counts, and those without co-infections also had better treatment outcomes. Our findings suggest that HIV+ DU tend to be inappropriately assumed to be less adherent and unlikely to achieve desirable treatment outcomes, when compared to their non-DU cohort.

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“…46 9 10 6 /l versus 80 9 10 6 /l (P = 0.82) Roca et al (1999) Virological efficacy was reached in [40% of patients of both groups in all visits (IDU and non-IDUS)…”

Section: Discussionmentioning

confidence: 92%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Treatment Outcomesmentioning

confidence: 99%

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Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

et al. 2008

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“…Patient factors strongly associated with medication adherence are depression, alcohol and illicit drug use, self-efficacy for successful medication taking, literacy, beliefs about how well medications will fit into the daily routine, and an understanding of the consequences of nonadherence; all of these factors are potential targets for intervention (Table 2) [14][15][16][17][18][19]. Many of the studies that have examined predictors of adherence used small cohorts and thus were prone to type II error (incorrectly accepting the null hypothesis).…”

Section: The Patientmentioning

confidence: 99%

Medication adherence among HIV-infected patients: Understanding the complex behavior of patients taking this complex therapy

Cheever

1999

Curr Infect Dis Rep

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Adherence to antiretroviral regimens by HIV-infected patients is necessary to prolong viral suppression and forestall viral resistance. This review covers the major advances made in research on adherence to HIV therapy in the past year. Currently, approximately 40% of patients receiving antiretroviral therapy have significant problems with adherence. Established predictors of poor adherence include depression, alcohol and illicit drug use, poor self-efficacy, and certain health beliefs. Medical providers are poor at predicting adherence. Interventions to improve adherence can have modest effects, and many types of interventions are effective. Multifaceted and repetitive interventions provide the most benefit. Medical providers, as part of the medical management of HIV-infected patients, should use interventions to achieve high levels of adherence to therapy.

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“…It has been shown that 50-70% of patients with HIV/AIDS who were taking HAART experienced problems with adverse effects which affected their adherence rate to the medications [15]. Subsequently, low adherence to HAART regimen may cause CD 4 decline and poor health condition [16].…”

Section: Tmmentioning

confidence: 99%

Treatment with IMODTM as a Novel Immune Modulator in HIV Positive Patients

SeyedAlinaghi¹

2012

J AIDS Clinic Res

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Stavudine, lamivudine and indinavir in drug abusing and non-drug abusing HIV-infected patients: Adherence, side effects and efficacy

Cited by 44 publications

References 21 publications

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

Medication adherence among HIV-infected patients: Understanding the complex behavior of patients taking this complex therapy

Treatment with IMODTM as a Novel Immune Modulator in HIV Positive Patients

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