Staying Cool in Space: A Review of Therapeutic Hypothermia and Potential Application for Space Medicine

Rosahl, Sophie C.; Covarrubias, Claudia; Wu, Jimmy; Urquieta, Emmanuel

doi:10.1089/ther.2020.0041

Cited by 2 publications

(3 citation statements)

References 67 publications

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“…Studies find that hypothermia can improve patient functional outcomes. 17,22 Several investigations have demonstrated that hypothermia can have negative consequences. Multiple large multicenter RCTs have demonstrated that HT not only fails to reduce patient mortality within six months, but may also be detrimental to patients with less impairment.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple large multicenter RCTs have demonstrated that HT not only fails to reduce patient mortality within six months, but may also be detrimental to patients with less impairment. 22 Long-term hypothermia is a form of immunosuppression that increases the incidence of pneumonia and sepsis. In addition, it has been reported that hypothermia can cause propofol infusion syndrome due to propofol's ability to reduce hepatic metabolism; this may be a significant cause of fatal symptoms at low temperatures.…”

Section: Discussionmentioning

confidence: 99%

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Role of Therapeutic Hypothermia in Improving Outcome After Traumatic Brain Injury : A Systematic Review

Roberto Pratama

2023

JARMHS

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Introduction: A nondegenerative and noncongenital brain injury caused by external mechanical forces can cause permanent or temporary harm to cognitive, physical, and psychosocial functions and change or diminish awareness. Traumatic brain injury can cause cerebral edema and ICP increase, worsening the lesion. Cellular death can occur minutes to hours after an injury, although negative effects can last 72 hours or more. Therapeutic hypothermia (HT) can lower ICP and protect neurons, improving patient prognosis and lowering mortality. The aim: This article showed role of therapeutic hypothermia in improving outcome after traumatic brain injury. Methods: This study demonstrated compliance with all requirements by comparing itself to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 standards. Therefore, the experts were able to ensure that the study was as current as feasible. For this search strategy, publications published between 2013 and 2023 were considered. Several online reference sources, including Pubmed and SagePub, were utilized for this purpose. It was determined not to consider review pieces, previously published works, or works that were only partially completed. Result: In the PubMed database, the results of our search brought up 112 articles, whereas the results of our search on SagePub brought up 107 articles. The results of the search conducted for the last year of 2013 yielded a total 59 articles for PubMed and 38 articles for SagePub. In the end, we compiled a total of 28 papers, 19 of which came from PubMed and nine of which came from SagePub. We included seven study that met the criteria. Conclusion: HT has not reduced, but may have increased, mortality in TBI patients in some high-quality studies. However, TBI patients with elevated ICP may benefit from hypothermia as therapy rather than as prophylaxis when initiated within 24 hours.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of Therapeutic Hypothermia in Improving Outcome After Traumatic Brain Injury : A Systematic Review

Roberto Pratama

2023

JARMHS

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“…Auch eine kurzfristige kardiopulmonale Reanimation (CPR) bei potenziell reversibler Ursache erscheint denkbar und würde ein rasches Atemwegsmanagement erfordern. Entsprechende Leitlinien zur CPR im Weltraum wurden erarbeitet und jüngst publiziert [26], ebenso Konzepte zur anschließenden Hypothermie [27].…”

Section: Notfall/reanimationunclassified

Evaluation neuer Methoden zur Atemwegssicherung bei Langzeitmissionen im Weltall

Warnecke

Kerkhoff

Schmitz

et al. 2021

Flugmedizin · Tropenmedizin · Reisemedizin - FTR

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ZUSAMMENFASSUNGIn den kommenden Jahren rücken Langzeitmissionen mit Errichtung einer Raumstation in der Mondumlaufbahn und bemannte Mars- missionen in erreichbare Nähe. Eine kurzfristige Evakuierung wird nicht möglich sein und die Besatzung muss, ggf. auch ohne ärztliche Unterstützung, autark eine Vielzahl möglicher medizinischer Ereig- nisse versorgen können. Hierzu zählen Notfälle mit Sicherung der Atemwege, wie auch eine notwendige Analgosedierung oder Voll- narkose. Nach Auswertung bisheriger Studien zur Evaluation geeig- neter Devices, empfiehlt sich der Einsatz supraglottischer Atemwegshilfsmittel bei freischwebender Anwendung in Schwerelosigkeit. Im Falle einer notwendigen endotrachealen Intubation muss aufgrund der Einflüsse der Schwerelosigkeit mit Schwellungen der Atemwege gerechnet werden, weshalb ein Videolaryngoskop Teil der Ausstat- tung sein sollte. Wann immer möglich, sollte zumindest der Patient während der Atemwegssicherung auf einem geeigneten Untergrund (z. B. Stretcher) fixiert sein.

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Staying Cool in Space: A Review of Therapeutic Hypothermia and Potential Application for Space Medicine

Cited by 2 publications

References 67 publications

Role of Therapeutic Hypothermia in Improving Outcome After Traumatic Brain Injury : A Systematic Review

Role of Therapeutic Hypothermia in Improving Outcome After Traumatic Brain Injury : A Systematic Review

Evaluation neuer Methoden zur Atemwegssicherung bei Langzeitmissionen im Weltall

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