2020
DOI: 10.1101/2020.11.30.393132
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Ste20-like kinase is critical for inhibitory synapse maintenance and its deficiency confers a developmental dendritopathy

Abstract: The size and structure of the dendritic arbor play important roles in determining how synaptic inputs of neurons are converted to action potential output. The regulatory mechanisms governing the development of dendrites, however, are insufficiently understood. The evolutionary conserved Ste20/Hippo kinase pathway has been proposed to play an important role in regulating the formation and maintenance of dendritic architecture. A key element of this pathway, Ste20-like kinase (SLK), regulates cytoskeletal dynami… Show more

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