The mixing in this enclosure is investigated numerically using 3-D flow in cubical cavity as a geometrically simple model of various natural and engineering flows. The mixing rate is evaluated for several representative scenarios of moving cavity walls: perpendicular motion of top and bottom cavity walls (Case A), motion of the top wall in its plane along its diagonal (Case B1), the top wall in motion to the right while the left vertical wall is in down motion (Case B2), and the top and bottom walls in motion either in parallel directions (Case B3) or in opposite directions (Case B4). The intensity of mixing for the considered cases was evaluated for (i) developing cavity flow initially at rest, which is started by the impulsive motion of cavity wall(s), and (ii) injection of two fluids into the developed cavity flow. For both cases, the initial interface of the two mixing fluids is a horizontal plane located at the middle of the cavity. The mixing rates are compared to the benchmark case in which the top cavity wall moves along its side (Case C). The effects of threedimensionality of cavity flow on the mixing rate are discussed. The mixing rates are ranked from fastest to slowest in the order B2, B4, A, B1, C, and B3 for developing flow and A, B4, C, B1, B2, and B3 for developed flow.