2016
DOI: 10.22159/ajpcr.2017.v10i1.15252
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Steady-State Pharmacokinetics of Metformin in Obese Patients With Type 2 Diabetes Mellitus: A Preliminary Study

Abstract: Objective: This study aimed to determine the metformin plasma steady-state concentration (PSSC) either trough and peak level in Type 2 diabetes mellitus patients with obesity and the impact of SLC22A1 gene organic cation transporter 1 (OCT) rs628031 A>G on PSSC of metformin.Methods: Validated reversed-phase high-performance liquid chromatography method with ultraviolet detector was used to determine the metformin PSSC, as well as genotype variation was performed using the restriction fragment length polymorphi… Show more

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