Steady state preparative multiple dual mode counter-current chromatography: Productivity and selectivity. Theory and experimental verification

Kostanyan, A. E.; Erastov, A. A.

doi:10.1016/j.chroma.2015.05.074

Cited by 37 publications

(7 citation statements)

References 28 publications

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“…Although the mathematical models on which the theory of the new CLR DM CCC method is based were previously verified experimentally in [9,11,25,28,30,33], it is necessary to carry out further experimental studies for practical implementation of the CLR DM CCC method with specified sample loading durations.…”

Section: Discussionmentioning

confidence: 99%

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Kostanyan

Вошкин

2021

Molecules

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We previously reported on a new counter-current chromatography (CCC) operating mode called closed-loop recycling dual-mode counter-current chromatography (CLR DM CCC), which incorporates the advantages of closed-loop recycling (CLR) and dual-mode (DM) counter-current chromatography and includes sequential separation of compounds in the closed-loop recycling mode with the mobile x-phase and in the inverted-phase counter-current mode with the mobile y-phase. The theoretical analysis of several implementations of this separation method was carried out under impulse sample injection conditions. This study is dedicated to the further development of CLR DM CCC theory applied to preparative and industrial separations, where high-throughput operation is required. Large sample volumes can be loaded via continuous loading within a specified time. To simulate CLR DM CCC separations with specified sample loading durations, equations are developed and presented in “Mathcad” software.

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Section: Discussionmentioning

confidence: 99%

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Kostanyan

Вошкин

2021

Molecules

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“…The MDM separation process consists of a series of counter-current dual-mode cycles. Each cycle consists of two isocratic steps: the first step: the upper phase as the mobile phase (ascending mode); the second step: the lower phase as the mobile phase (descending mode) (Reprinted [32]) for all the cycles) and non-steady-state (the elution steps duration of the alternating phase is variable during each cycle) operations [31][32][33][34]. Their research showed that CCC enables greatly improved resolution due to its high value of stationary phase retention.…”

Section: Origin Of Mdm CCCmentioning

confidence: 99%

An overview of recent progress in multiple dual‐mode counter‐current chromatography

Zhang

Muhire

Sun

et al. 2023

J of Separation Science

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Counter‐current chromatography is a chromatographic separation and purification technique being developed. The development of different elution modes has significantly contributed to this field. Multiple dual‐mode elution is a method developed based on dual‐mode elution, which consists of a series of changing cycles of the phase role and the direction by switching between normal and reverse elution modes of counter‐current chromatography. This dual‐mode elution method takes full advantage of the liquid nature of stationary and mobile phases of counter‐current chromatography and effectively improves the separation efficiency. So, this unique elution mode has gained extensive attention for separating complex samples. This review mainly describes and summarizes in detail its development, applications, and characteristics in recent years. Meanwhile, its advantages, limitations, and future outlook also have been discussed in this paper.

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“…Exhaustive reviews on the enantiomeric separations in CCC were published by Foucault 348 and Huang et al 351 The attention of some related researchers was concentrated on looking for ways of improving the separation efficiency of chiral separation by CCC. Novel methods such as multiple dual mode elution 352 that consist of switching alternatively between reversed and normal phase operation during the experiment was applied for the resolution of (S)-naproxen derivative. 353 The recycling elution mode (or closed-loop recycling elution mode) consists in recycling the effluent that leaves the chromatograph was applied for the separation of amlodipine besilate, 354 oxybutynin, 355 and naproxen 356 enantiomers.…”

Section: Countercurrent Chromatographymentioning

confidence: 99%

Semi-continuous and continuous processes for enantiomeric separation

2022

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Steady state preparative multiple dual mode counter-current chromatography: Productivity and selectivity. Theory and experimental verification

Cited by 37 publications

References 28 publications

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

An overview of recent progress in multiple dual‐mode counter‐current chromatography

Semi-continuous and continuous processes for enantiomeric separation

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