“…30,31 Among FET-based biosensors, the AlGaN/GaN high electron mobility transistor (HEMT) is particularly favored for biosensing due to its non-toxic nature, compatibility with biological systems, and stability in various chemical environments. 32–36 The exceptional responsiveness of the highly sensitive two-dimensional electron gas (2DEG), located near the surface of the AlGaN/GaN HEMT sensor, enables effective detection of changes in surface potential. 37–45 Recent applications have successfully demonstrated the use of AlGaN/GaN HEMT sensors in detecting proteins (biomarkers/antigens), 37,42 ions, 43,44,46 DNA hybridization events, 47,48 and pH levels 38,40,45 within solution or serum samples.…”