2021
DOI: 10.1021/acsnano.1c04213
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Stealth Effect of Short Polyoxazolines in Graft Copolymers: Minor Changes of Backbone End Group Determine Liver Cell-Type Specificity

Abstract: Dye-loaded micelles of 10 nm diameter formed from amphiphilic graft copolymers composed of a hydrophobic poly­(methyl methacrylate) backbone and hydrophilic poly­(2-ethyl-2-oxazoline) side chains with a degree of polymerization of 15 were investigated concerning their cellular interaction and uptake in vitro as well as their interaction with local and circulating cells of the reticuloendothelial system in the liver by intravital microscopy. Despite the high molar mass of the individual macromolecules (M n ≈ 20… Show more

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Cited by 18 publications
(28 citation statements)
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“…Literature could show that different polymer end groups can have a decent impact on cellular uptake [82,83] and in vivo performance. [84] Jordan Green and co-workers could show that small molecule end group modifications of linear polymers can influence cellular uptake behavior largely independent of polymer/DNA binding, particle size, and particle surface charge. [82,83] Bekale et al investigated PEG end group effects on the interaction with model proteins (human and bovine serum albumin) in order to comprehend the relationship between structural properties of PEG and polymer affinity toward proteins.…”
Section: Dbco-peg-ligand Conjugates For Click Modification Of Polyplexesmentioning
confidence: 99%
“…Literature could show that different polymer end groups can have a decent impact on cellular uptake [82,83] and in vivo performance. [84] Jordan Green and co-workers could show that small molecule end group modifications of linear polymers can influence cellular uptake behavior largely independent of polymer/DNA binding, particle size, and particle surface charge. [82,83] Bekale et al investigated PEG end group effects on the interaction with model proteins (human and bovine serum albumin) in order to comprehend the relationship between structural properties of PEG and polymer affinity toward proteins.…”
Section: Dbco-peg-ligand Conjugates For Click Modification Of Polyplexesmentioning
confidence: 99%
“…Existence of micelles containing cargo was found down to concentrations as expected by the dilution in the blood volume of mice. This was indicated by hydrodynamic diameter (eq ) and molar mass (right-hand side of eq S5) estimations from AUC data …”
Section: New Applications Of the Auc In The Life Sciencesmentioning
confidence: 92%
“…In a follow-up study, focusing on related materials, the polymer backbone end-group chemistry was also shown to impact the stealth and cell-type specific behavior of micelles in mice. 58 Existence of micelles containing cargo was found down to concentrations as expected by the dilution in the blood volume of mice. This was indicated by hydrodynamic diameter (eq 6) and molar mass (right-hand side of eq S5) estimations from AUC data.…”
Section: ■ Types Of Auc Experimentsmentioning
confidence: 93%
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