STEALTH liposome-encapsulated cisplatin (SPI-77) versus carboplatin as adjuvant therapy for spontaneously arising osteosarcoma (OSA) in the dog: a randomized multicenter clinical trial

Abstract

While STEALTH liposome encapsulation of cisplatin allowed the safe administration of five times the maximally tolerated dose of free cisplatin to dogs without concurrent hydration protocols, this did not translate into significantly prolonged DFS or OS. However, a larger proportion of dogs receiving SPI-77 enjoyed long-term DFS when compared with dogs receiving carboplatin.

Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery: An individual patient data meta-analysis

“…Data from 20 studies were included in this IPDMA, of which 11 studies were previously published (Kurzman et al, 1995;Berg et al, 1997;Kirpensteijn et al, 2002;Vail et al, 2002;Morello et al, 2003;Moore et al, 2007;Bacon et al, 2008;Kow et al, 2008;Phillips et al, 2009;Sottnik et al, 2010). 19 studies reported solely on large breed dogs, while the unpublished study of Dr. Amsellem included 36 small breed canines.…”

In vivo administration of liposomal vincristine sensitizes drug‐resistant human solid tumors

“…8,9 Encapsulation of cisplatin in liposomes shows a better antitumoral efficacy compared to free drug in dogs with osteosarcoma. 10 Liposomal topotecan exhibits a better pharmacokinetic profile and an improved antitumor efficacy than the free drug in murine and human experimental tumors. 11 Moreover, encapsulation of vincristine (VCR) in liposomes increased the antitumor efficacy in mice bearing L-1210 and P-388 murine leukemias, compared to the free drug.…”

Doxorubicin and BAY 12–9566 for the Treatment of Osteosarcoma in Dogs: A Randomized, Double‐Blind, Placebo‐Controlled Study

“…[4][5][6][7][8] Another important prognostic factor identified for dogs with appendicular osteosarcoma is histologic grade. High grade tumors with histologic evidence of tumor growth into vessels or lymphatics, a high number of mitoses, increased cellular pleomorphism, small amounts of tumor matrix, and more than 50% necrosis in the tumor biopsy specimen had a worse prognosis compared with low grade tumors.…”