Stearic acid modified nano CuMOFs used as a nitric oxide carrier for prolonged nitric oxide release

Huang, Maotao; Zhang, Jianwen; Ke, Xianlan; Gao, Shuai; Wu, Dimeng; Chen, Junying; Weng, Yajun

doi:10.1039/d1ra08066k

Cited by 14 publications

(4 citation statements)

References 34 publications

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“…Compared with the XRD of the pristine fabric, the coated samples showed many characteristic peaks, which were not found in the pristine fabric, indicating that the two coatings had been successfully introduced into the fabric surface. The relative intensities of Cu‐MOFs@SA and CS@Cu‐MOFs@SA coatings were primarily consistent with the classic HKUST‐1, [ 16,17 ] as shown in Figure 2a. Meanwhile, the introduction of chitosan did not appear to change the material's crystal structure.…”

Section: Resultssupporting

confidence: 75%

Combining Chitosan, Stearic Acid, and (Cu‐, Zn‐) MOFs to Prepare Robust Superhydrophobic Coatings with Biomedical Multifunctionalities

Zhang,

Pei,

Liu

et al. 2023

Adv Healthcare Materials

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There is an urgent need to develop a series of multifunctional materials with good biocompatibility, high mechanical strength, hemostatic properties, anti‐adhesion, and anti‐infection for applications in wound care. However, successfully developing multifunctional materials is challenging. In this study, two superhydrophobic composite coatings with good biocompatibility, high mechanical strength, strong antifouling and blood repellency, fast hemostasis, and good antibacterial activity were prepared on cotton fabric surface by simple, green, and low‐cost one‐step dip‐coating technology. The results discussed in the manuscript revealed that the two superhydrophobic composite coatings could maintain good mechanical stability, strong water repellency, and durability under various types of mechanical damage, high‐temperature treatment, and long‐term strong light irradiation. The coatings also exhibited good repellency to various solid pollutants, highly viscous liquid pollutants and blood. In vitro and in vivo hemostatic experiments showed that both composite coatings had good hemostatic and anti‐clot adhesion properties. More importantly, this superhydrophobic coating prevented bacterial adhesion and growth and released Cu2+ and Zn2+ ions and chitosan to achieve bactericidal properties, thereby protecting injured skin from bacterial infection. The two superhydrophobic coatings enhanced the anti‐fouling, anti‐adhesion, hemostatic, and antibacterial functions of blood‐repellent dressings and therefore have broad application prospects in medical and textile fields.This article is protected by copyright. All rights reserved

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Section: Resultssupporting

confidence: 75%

Combining Chitosan, Stearic Acid, and (Cu‐, Zn‐) MOFs to Prepare Robust Superhydrophobic Coatings with Biomedical Multifunctionalities

Zhang,

Pei,

Liu

et al. 2023

Adv Healthcare Materials

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“…Two peaks of 2852 and 2917 cm –1 appear in the FTIR spectra of pure SA and ZnO/Cu–ZnMOFs@SA, which could be assigned to the vibration of the −CH 3 and −CH 2 groups of SA. The results confirmed that SA exists on the ZnO/Cu–ZnMOFs@SA surface, , contributing to its superhydrophobicity.…”

Section: Resultssupporting

confidence: 68%

Construction of Hierarchical Micro/Nanostructured ZnO/Cu–ZnMOFs@SA Superhydrophobic Composite Coatings with Excellent Multifunctionality of Anticorrosion, Blood-Repelling, and Antimicrobial Properties

Zhang

Pei

Huang

et al. 2022

ACS Appl. Mater. Interfaces

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Naked medical devices are often damaged by blood, bacteria, and other extreme environmental conditions (heat, humidity, acid, alkali, salts, and others), causing device failure and increasing difficulty for the operator. They can also cause inflammation and coagulation resulting in severe complications and even death. In this work, the superhydrophobic ZnO/copper−zinc metal−organic frameworks@stearic acid (ZnO/Cu−ZnMOFs@SA) composite coatings with hierarchical micro/nanostructures were fabricated on Zn substrates via a one-step hydrothermal method. The effects of hierarchical micro/nanostructures on surface wettability, physicochemical stability, and biological properties have been studied in this manuscript. The structure not only provided the coatings with robust waterproofing, abrasive resistance, durability, and thermal and light irradiation stability but also successfully recovered their superhydrophobicity by remodifying the surface with SA, showing excellent repeatability. In addition, the coating demonstrates excellent corrosion resistance and self-cleaning ability and rejects various solid and liquid contaminants. The superhydrophobic ZnO/Cu−ZnMOFs@SA composite coatings also exhibited excellent antibacterial and thrombosis resistance. The findings indicated that the superhydrophobic composite coatings have a strong potential for application in medical instruments for exhibiting multifunctional properties in various extreme environments.

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“…Numerous studies were done to modulate the release of NO. [57][58][59][60] The in vitro release of NO entrapped on the SP NPs was investigated in PBS at pH 7.4 and temperature 37 ± 2 °C to simulate the intestinal environment and the CDR (%) was found to be 97.37 ± 8.19% within 24 h. Fig. 3 demonstrates that SP NPs successfully regulate and lower the release rate of NO.…”

Section: Discussionmentioning

confidence: 95%

Nitric oxide releasing novel amino acid-derived polymeric nanotherapeutic with anti-inflammatory properties for rapid wound tissue regeneration

Gupta,

Wasnik,

Patra

et al. 2024

Nanoscale

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Stearic acid modified nano CuMOFs used as a nitric oxide carrier for prolonged nitric oxide release

Abstract: Nitric oxide (NO) shows high potential in the cardiovascular system with anticoagulant and antibacterial efficacy.

Cited by 14 publications

References 34 publications

Combining Chitosan, Stearic Acid, and (Cu‐, Zn‐) MOFs to Prepare Robust Superhydrophobic Coatings with Biomedical Multifunctionalities

Combining Chitosan, Stearic Acid, and (Cu‐, Zn‐) MOFs to Prepare Robust Superhydrophobic Coatings with Biomedical Multifunctionalities

Construction of Hierarchical Micro/Nanostructured ZnO/Cu–ZnMOFs@SA Superhydrophobic Composite Coatings with Excellent Multifunctionality of Anticorrosion, Blood-Repelling, and Antimicrobial Properties

Nitric oxide releasing novel amino acid-derived polymeric nanotherapeutic with anti-inflammatory properties for rapid wound tissue regeneration

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