2024
DOI: 10.1186/s13024-024-00778-w
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Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders

Melanie Loix,
Sam Vanherle,
Marta Turri
et al.

Abstract: Disturbances in the fatty acid lipidome are increasingly recognized as key drivers in the progression of various brain disorders. In this review article, we delve into the impact of Δ9 fatty acid desaturases, with a particular focus on stearoyl-CoA desaturase-1 (SCD1), within the setting of neuroinflammation, neurodegeneration, and brain repair. Over the past years, it was established that inhibition or deficiency of SCD1 not only suppresses neuroinflammation but also protects against neurodegeneration in cond… Show more

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