Steatosis and hepatic markers before and shortly after bariatric surgery

Abreu, Márcia Regina Azevedo de; Ramos, Alfeu Saraiva; Vendramini, Regina Célia; Brunetti, Iguatemy Lourenço; Pepato, Maria Teresa

doi:10.1258/000456307779596002

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Fortunately, ALP concentrations have been shown to improve following bariatric surgery (Toolabi et al, 2011). Yet, the literature is not entirely consistent on this matter, as extant evidence also shows no changes in ALP concentrations after bariatric surgery (De Abreu et al, 2007). The current sample as a whole demonstrated no change in ALP levels from pre- to post-surgery, but there were many participants that exhibited declines over time (i.e., 41.0%) and this subgroup of participants appears to account for the improvements in cognitive function.…”

Section: Discussionmentioning

confidence: 99%

The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

Alosco

Spitznagel

Strain

et al. 2014

Journal of the Neurological Sciences

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Background The mechanisms for improved cognitive function post-bariatric surgery are not well understood. Markers of kidney and liver function (i.e., cystatin C and alkaline phosphatase (ALP)) are elevated in obese individuals and associated with poor neurocognitive outcomes in other samples. Bariatric surgery can improve cystatin C and ALP levels, but no study has examined whether such changes correspond to post-operative cognitive benefits. Methods 78 bariatric surgery patients completed a computerized cognitive test battery prior to and 12-months after surgery. All participants underwent an eight-hour fasting blood draw to quantify cystatin C and ALP concentrations. Results Cognitive function improved after surgery. Cystatin C levels decreased at the 12-month follow-up; however, no changes were found in ALP concentrations. At baseline, higher cystatin C levels predicted worse attention/executive function, but no such effects emerged for ALP. Regression analyses controlling for possible medical and demographic confounds and baseline factors revealed that decreased ALP levels following surgery predicted better attention/executive function and memory abilities. Post-surgery changes in cystatin C did not correspond to cognitive improvements. Conclusions Decreased ALP levels predicted better cognition following bariatric surgery, suggesting improved liver function as a possible mechanism of post-operative cognitive benefits. Future studies with neuroimaging and longer follow-up periods are needed to determine whether bariatric surgery can decrease risk for adverse brain changes and dementia in severely obese persons via improved metabolic function.

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Section: Discussionmentioning

confidence: 99%