Steatosis in chronic hepatitis C: fuel for overproduction of oxidative stress?

Koike, Kazuhiko

doi:10.1007/s00535-005-1626-8

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…There have also been negative studies: HCV antibody status was not associated with first myocardial infarction in active duty military men (35) nor was it among several chronic infections associated with the onset of carotid artery sclerosis (36). HCV infection is often accompanied by an inflammatory response including cryoglobulinemia and vasculitis (37,38), which could affect the coronary arteries, and has also been associated with a metabolic syndrome consisting of insulin resistance and type 2 diabetes, which may in turn predispose patients to accelerated coronary disease (39).…”

Section: Discussionmentioning

confidence: 99%

Increased All-Cause, Liver, and Cardiac Mortality among Hepatitis C Virus-seropositive Blood Donors

Guiltinan

Kaidarova

Custer

et al. 2008

American Journal of Epidemiology

118

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Hospital-based studies suggest that hepatitis C virus (HCV) infection causes frequent cirrhosis, hepatocellular carcinoma, and mortality, but epidemiologic studies have shown less morbidity and mortality. The authors performed a retrospective cohort study of 10,259 recombinant immunoblot assay-confirmed, HCV antibody-positive (HCV+), allogeneic blood donors from 1991 to 2002 and 10,259 HCV antibody-negative (HCV-) donors matched for year of donation, age, gender, and Zone Improvement Plan Code (ZIP Code). Vital status through 2003 was obtained from the US National Death Index, and hazard ratios with 95% confidence intervals were calculated by survival analysis. After a mean follow-up of 7.7 years, there were 601 (2.92%) deaths: 453 HCV+ and 148 HCV- (hazard ratio (HR) = 3.13, 95% confidence interval (CI): 2.60, 3.76). Excess mortality in the HCV+ group was greatest in liver-related (HR = 45.99, 95% CI: 11.32, 186.74), drug- or alcohol-related (HR = 10.81, 95% CI: 4.68, 24.96), and trauma/suicide (HR = 2.99, 95% CI: 2.05, 4.36) causes. There was also an unexpected increase in cardiovascular mortality among the HCV+ donors (HR = 2.21, 95% CI: 1.41, 3.46). HCV infection is associated with a significant, threefold increase in overall mortality among former blood donors, including significantly increased mortality from liver and cardiovascular causes. High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable.

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Section: Discussionmentioning

confidence: 99%

Increased All-Cause, Liver, and Cardiac Mortality among Hepatitis C Virus-seropositive Blood Donors

Guiltinan

Kaidarova

Custer

et al. 2008

American Journal of Epidemiology

118

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“…A number of such studies have demonstrated a significant association between hepatic steatosis and fibrosis 31 – 33. Applying the two-hit theory, ROS may be produced as a direct effect of the virus on hepatic mitochondria and/or the immune response to viral infection,34 with steatosis providing an abundance of fuel on which such radicals can act 35. In support, steatosis has been associated with markers of oxidative stress in patients with hepatitis C 36.…”

Section: Pathogenesismentioning

confidence: 99%

A growing burden: the pathogenesis, investigation and management of non-alcoholic fatty liver disease

2007

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Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder in western countries, and its incidence is increasing. This review outlines the significant health burden posed by NAFLD and discusses what is presently known about its pathogenesis, including the roles of the metabolic syndrome, obesity, insulin resistance, hepatic steatosis, reactive oxygen species, inflammatory cytokines and adipocytokines. The way in which NAFLD is clinically diagnosed is described, and areas of uncertainty surrounding its investigation are identified, before discussing the relative merits of the limited treatment options available and looking ahead to potential therapeutic strategies for the future.

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