Stec Reaction

Abstract

The stereospecific synthesis of P‐chiral biophosphates from dialkyl (or aryl) phosphoramidate anions and carbonyl electrophiles, followed by the replacement of an amidate function by oxygen is generally referred to as the Stec reaction. This reaction not only provides a straightforward access to a variety of diastereomerically pure P‐chiral biophosphates and their analogues, but also retains the configuration at the phosphorus atom in these biophosphate analogues. This reaction is important for the synthesis of biophosphates and their analogues.