A Hybrid Boosting Converter (HBC) with collective advantages of regulation capability from its boost structure and gain enhancement functionality from its voltage multiplier structure is proposed in this paper. The new converter incorporates a Bipolar Voltage Multiplier (BVM), featuring in symmetrical configuration, single inductor and single switch, high gain capability with a wide regulation range, low component stress, small output ripple and flexible extension, which makes it suitable for front-end PV system and some other renewable energy applications. The operation principal, component stress, and voltage ripple are analyzed in this paper. Performance comparison and evaluation with a number of previous single-switch single-inductor converters are provided. A 200W 35V to 380V second-order HBC prototype was built with peak efficiency at 95.44%. The simulation and experimental results both confirm the feasibility of the proposed converter. Index Terms-HBC, Bipolar Voltage Multiplier (BVM), single-switch single inductor, nature interleaving, renewable energy