Steep improvement in dissolution profile of ezetimibe through co-inclusion in urea

Preparation, Characterization and Evaluation of Human Guarded Chlorpyrifos Urea Co-inclusion Complexes

“…The said method comprised of two phases. The phase I was utilized for determination of stoichiometric ratio between urea and RCA and phase II for determination of minimum ratio of RCA and CHF for formation of urea co-inclusion complexes [25,30] .…”

“…The increments of 0.5 ml of oleic acid were successively introduced into the calorimeter using a burette. Temperature was recorded after each addition [28][29][30] . A graph representing an increase in temperature following incremental addition of oleic acid as a suitable rapidly complexing agent to methanolic solution of urea was plotted.…”

“…The initial increments of 0.2 ml and subsequently 0.5 ml of oleic acid as a suitable RCA were successively added into the calorimeter. The graph of rise in temperature versus the amount of RCA added to a solution of urea and CHF in methanol was obtained [28][29][30] .…”

“…The thermogram of UOAC exhibits melting of urea in two stages. The first stage is attributed to collapse of the hexagonal structure of the UOAC at 117.34° to yield the tetragonal urea while the second step exhibits melting of tetragonal urea at 134.83°[ [28][29][30] . Pure CHF displays a melting endotherm in the temperature range of 39.73°-50.05° with a sharp melting endothermic peak at 46.26° [ 42] .…”

“…NNCG drugs for oral use as inclusion complexes have been reported. These NNCG drugs included enalapril maleate, glipizide, amiloride hydrochloride, lafutidine, simvastatin and ezetimbe [25][26][27][28][29][30] . Co-inclusion of NNCG drugs in urea has also been reported for reduction in moisture sensitivity of nicorandil and improvement of safe handling and photostability characteristics of cis-retinoic acid [31,32] .…”