Steep rise of docosahexaenoic acid in phosphatidylethanolamines of heart and liver of rats fed native olive oil or rapeseed oil

Weber, Nikolaus; Mukherjee, Kumar D.

doi:10.1016/s0271-5317(98)00070-0

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Dietary lipids induce extensive modifications in the cell membranes [4,5,13,14,18,[25][26][27][28][29]. Our results reflect a steep increase of the EPA and DHA percentage in phospholipids of total skeletal muscle, in the phospholipids of SR, and in PE of skeletal muscle polar fraction by feeding fish oil.…”

Section: Lipid Compositionsupporting

confidence: 52%

“…It has been shown that there is a greater n-3 fatty acid incorporation into rat muscle PL fed a diet with a low n-6/ n-3 ratio (0.49) in comparison to a diet with a ratio of 4.4 [25]. Weber and Mukherjee [27] reported a twofold increase of the relative proportion of docosahexaenoic acid in total heart and liver lipids and up to 4.5fold higher percentage in PE of heart, liver, and brain in rats fed a rapeseed oil supplemented diet compared to high-oleic sunflower oil and olive oil addition. The moderate proportion of a-linolenic acid in rapeseed is finally converted to DHA by elongation and desaturation.…”

Section: Lipid Compositionmentioning

confidence: 99%

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Influence of dietary n-3 fatty acids on the membrane properties of skeletal muscle in pigs

Nürnberg¹,

Küchenmeister

Ender

et al. 1998

Fett/Lipid

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Near-infrared spectroscopy (NIRS) was applied to crude and processed lecithins to enable qualitative and quantitative classification. With the calibration models used, NIRS enables a rapid selection of lecithins for further processing in a property specific product line. Quantitative determination was achieved for selected lecithin reference values (acetone insoluble, phosphatidylcholine content, acid value, water content). Validated models showed no significant differences (p = 95%) to conventional chemical methods in statistical testing.Analytik von Lecithinen mittels Nahinfrarot-Spektroskopie. Die Nahinfrarot-Spektroskopie (NIRS) wurde eingesetzt, um Rohlecithine und verarbeitete Lecithine qualitativ und quantitativ zu bewerten. Durch die verwendeten Kalibrationsmodelle ermöglicht die NIRS eine schnelle Selektion von Lecithinen für die weitere Verarbeitung in der qualitätsspezifischen Produktlinie. Für die ausgewählten Lecithinkennzahlen (Acetonunlösliches, Phosphatidylcholingehalt, Säurezahl und Wassergehalt) wurden quantitative Modelle kalibriert. Die validierten Modelle zeigten gegenüber den konventionellen chemischen Methoden keine signifikanten Unterschiede (p = 95%).

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Section: Lipid Compositionsupporting

confidence: 52%

Section: Lipid Compositionmentioning

confidence: 99%

Influence of dietary n-3 fatty acids on the membrane properties of skeletal muscle in pigs

Nürnberg¹,

Küchenmeister

Ender

et al. 1998

Fett/Lipid

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“…The influence of dietary lipids on liver FA composition has been demonstrated in experimental animal studies using different oils (1,14,15). In the present study, intragastric administration of bullfrog oil caused an increase in long-chain PUFA (20:4n-6, 20:5n-3, and 22:6n-3) and a decrease in SFA (14:0, 16:0, and 18:0) in the liver.…”

supporting

confidence: 60%

“…Similarly, the increase in EPA and DHA may be explained by direct incorporation and/or synthesis from ALA present in bullfrog oil. An increase in the proportions of total n-3 PUFA in brain and liver (including EPA and DHA) has been observed in a number of studies involving feeding of olive oil, which contains a low proportion of n-3 PUFA and its precursors (15,16). Interestingly, in the present study the incorporation of n-9 FA was very low.…”

supporting

confidence: 51%

Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver

Silva

Miyasaka

Martins

et al. 2004

Braz J Med Biol Res

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The aim of the present study was to investigate the effects of daily intragastric administration of bullfrog oil (oleic, linoleic and palmitoleic acid-rich oil), corresponding to 0.4% of body weight for four weeks, on fatty acid composition and oxidative stress (lipid peroxidation and catalase activity) in mouse liver. The activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT), biomarkers of tissue injury, were determined in liver homogenates and serum. The proportions of 18:2n-6, 20:4n-6, 20:5n-3, and 22:6n-3 (polyunsaturated fatty acids, from 37 to 60%) in the total fatty acid content were increased in the liver of the bullfrog oil-treated group (P < 0.05) compared to control. At the same time, a significant decrease in the relative abundance of 14:0, 16:0, and 18:0 (saturated fatty acids, from 49 to 25%) was observed. The hepatic content of thiobarbituric acid reactive substances (TBARS) was increased from 2.3 ± 0.2 to 12.3 ± 0.3 nmol TBA-MDA/mg protein and catalase activity was increased from 840 ± 32 to 1110 ± 45 µmol reduced H 2 O 2 min -1 mg protein -1 in the treated group. Bullfrog oil administration increased AST and ALP activities in the liver (from 234.10 ± 0.12 to 342.84 ± 0.13 and 9.38 ± 0.60 to 20.06 ± 0.27 U/g, respectively) and in serum (from 95.41 ± 6.13 to 120.32 ± 3.15 and 234.75 ± 11.5 to 254.41 ± 2.73 U/l, respectively), suggesting that this treatment induced tissue damage. ALT activity was increased from 287.28 ± 0.29 to 315.98 ± 0.34 U/g in the liver but remained unchanged in serum, whereas the GGT activity was not affected by bullfrog oil treatment. Therefore, despite the interesting modulation of fatty acids by bullfrog oil, a possible therapeutic use requires care since some adverse effects were observed in liver.

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“…The proportion of DHA (C22:6 n-3) increased in both positions of PC, PE, and PS in the OO group. In a number of feeding studies with OO, an increase in n-3 PUFA has also been observed in total lipids and PLs from different organs and tissues ( − ). This is most likely due to the lower linoleic acid content (C18:2 n-6) of OO-enriched diets, since the competition between linoleic acid (C18:2 n-6) and linolenic acid (C18:3 n-3) for desaturases may result in lower levels of n-3 PUFA in lipids from animals fed diets with a higher linoleic acid (C18:2 n-6) content ().…”

Section: Discussionmentioning

confidence: 99%

Stereospecific Analysis of Phospholipid Classes in Skeletal Muscle from Rats Fed Different Fat Sources

Pérez‐Palacios

Antequera

Muriel

et al. 2007

J. Agric. Food Chem.

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The fatty acid (FA) and dimethylacetal profiles of the sn-1 and sn-2 positions of different phospholipid (PL) classes from skeletal muscle of rats as affected by dietary FA profiles were studied. Rats were fed either a control diet, an olive oil-enriched diet, or a sunflower oil-enriched diet. The FA composition of both positions of the studied PL classes was affected by diet to different extents. The FA composition of the sn-2 position of phosphatidylserine was the most influenced by diet, while phosphatidylinositol was less affected by dietary modification. The FA profile of phosphatidylcholine reflected consumed FA better than any other studied PL. Thus, olive oil rats showed higher oleic acid (C18:1 n-9) contents in both positions of phosphatidylcholine, and sunflower oil rats had higher proportions of arachidonic acid (C20:4 n-6) in the sn-1 position of this PL class. Dimethylacetals were scarcely affected by diet, and only the dimethylacetal composition of phosphatidylethanolamine showed significant modifications.

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Steep rise of docosahexaenoic acid in phosphatidylethanolamines of heart and liver of rats fed native olive oil or rapeseed oil

Cited by 10 publications

References 35 publications

Influence of dietary n-3 fatty acids on the membrane properties of skeletal muscle in pigs

Influence of dietary n-3 fatty acids on the membrane properties of skeletal muscle in pigs

Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver

Stereospecific Analysis of Phospholipid Classes in Skeletal Muscle from Rats Fed Different Fat Sources

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