Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

Mathieu, Jean-Baptiste; Martel, Sylvain

doi:10.1002/mrm.22279

Cited by 101 publications

(71 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The desired gradient orientations were defined as θ G = −π/4 and θ G = 3π/4 for the left and right bifurcation respectively. Note that these gradients are orthogonal to the flow in order to push the particles on the desired side of the tube, past the centerline, as detailed in [4]. We defined G min = 300 mT/m, ξ max = π/8 and respected the constraint r/R core > 4.…”

Section: Methodsmentioning

confidence: 99%

“…It was previously shown that magnetic gradients in the order of at least 200-400 mT/m are desirable in order to control ferromagnetic therapeutic agents inside blood vessels [4], [11]. Because the gradient magnitude around a dipole decreases at a fast rate of 1/r 4 , it is of interest to investigate how far from a core such gradient magnitudes can be obtained.…”

Section: Core Sizementioning

confidence: 99%

“…While the magnetic field strength inside the tunnel of the scanner can be sufficient to achieve depth independent saturation magnetization of the nanoparticles, MRN lacks the maximum gradient magnitude achievable with EMA-MNS. Additional coil inserts can provide much higher gradients [4], but the smaller inner diameter of the insert prevents whole body interventions to be conducted. Although whole body MRN could be done using ultra-high gradient scanners, these platforms are much more expensive, not widely available, and the operating time for MRN conducted in complex networks is limited due to excessive heating of the coils caused by switching gradients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dipole Field Navigation for targeted drug delivery

Latulippe

2014

5th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics

Self Cite

View full text Add to dashboard Cite

A new method for the navigation of therapeutic agents in the vascular network is introduced. This method, dubbed Dipole Field Navigation (DFN), is characterized by high directional gradients and a high magnetic field strength. The latter is used to bring magnetic therapeutic agents at saturation magnetization such that when combined with high directional gradients, effective navigation at any depths within the patient can be achieved. DFN does not have many of the constraints of gradient coil-based platforms, which include potential peripheral nerve stimulations, reduced directional changes and slew rates of the gradient fields, overheating of the coils, and high implementation cost. To achieve such specifications, soft ferromagnetic cores are positioned at specific locations inside the tunnel of a clinical MRI scanner providing a high uniform field of typically up to 3 T, sufficient to bring both the cores and the therapeutic agents at full saturation magnetization. The field distortions created by the cores result in gradients exceeding 300 mT/m for whole body interventions. Hence, with such cores placed at specific locations, the resulting gradients would cause the therapeutic agents to follow a precise path in the vascular network towards the targeted region. In this paper, the fundamental theory of DFN with preliminary in vitro experimental results using one core in a 1.5 T scanner confirms the potential of DFN for targeted drug delivery.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Core Sizementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dipole Field Navigation for targeted drug delivery

Latulippe

2014

5th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics

Self Cite

View full text Add to dashboard Cite

show abstract

“…The platform is based on a Magnetic Resonance Imaging (MRI) system that is an essential instrument for medical diagnosis [44]. The three imaging gradient coils of the MRI system is utilized to provide actuation force for the ferromagnetic microrobots [45].…”

Section: Multi-microrobot Control Using Magnetic Fieldsmentioning

confidence: 99%

Controlling multiple microrobots: recent progress and future challenges

2015

View full text Add to dashboard Cite

Robots the size of several microns have numerous application in medicine, biology, and manufacturing. However, simultaneous control of multiple robots at this scale is difficult since the robot itself is too small to carry power, sensors, communication, and control on-board. In this paper, we have summarized different approaches, ranging from specialized robot design and fabrication to specialized ways of actuating robots, with the aim of independent control of a team/swarm of microrobots. We have also discussed the challenges for each approach. In the light of the challenges, we have proposed some directions where the future researchers can focus in order to solve the problem of independent control of a team of microrobots.

show abstract

“…Much research has been done into magnetic drug delivery systems [53,55,59,61,67], but for the sake of brevity, we are not including them. There are some research problems associated with site-specific drug delivery based on magnetic drug carriers [48,49,53,[57][58][59][60][61]: (i) occlusion of a blood vessel due to the high concentration of the carriers just before release, (ii) the distance from the magnetic field source to the target point--there is a non-linear relationship between the magnetic field and distance to the target point, (iii) once the drug is released, the blood flow reduces its efficacy, no retention of the drug under the magnetic field, and (iv) toxicity due to the magnetic core of the drug carrier. While the first two problems can be solved using practical measures, the last two must be solved in order to pave the way for using this promising site-specific drug delivery technique in clinical applications.…”

Section: 21mentioning

confidence: 99%

Towards soft robotic devices for site-specific drug delivery

Alici

2015

Expert Review of Medical Devices

View full text Add to dashboard Cite

Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications. Towards soft robotic devices for site-specific drug delivery Abstract Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) which are mechanical / physical, chemical and biological/molecular DDS. In this paper, we report on recent advances in site-specific drug delivery 1 based on mechanical / physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish really soft robotic devices for clinical and biomedical applications.

show abstract

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

Cited by 101 publications

References 24 publications

Dipole Field Navigation for targeted drug delivery

Dipole Field Navigation for targeted drug delivery

Controlling multiple microrobots: recent progress and future challenges

Towards soft robotic devices for site-specific drug delivery

Contact Info

Product

Resources

About