“…Introduction of an interactive, 3D lac operon puzzle resulted in significant learning gains in both populations in which it was implemented, with a larger effect size in a genetics class at an underfunded minority-serving institution than in a microbiology class at an R1 primarily white institution ( Gordy et al, 2020 ; Ramirez and Gordy, 2020 ). The inclusivity of TTT-GIL activities, which are created using Universal Design for Learning (UDL), along with their hands-on, game-like nature, suggest that they may be an effective way of teaching cellular and molecular immunology concepts even to younger students ( Hall et al, 2003 ; Rose and Meyer, 2006 ; Burgstahler and Cory, 2010 ; Rappolt-Schlichtmann et al, 2012 ; Meyer et al, 2014 ; Ramirez and Gordy, 2020 ). We therefore developed and implemented two additional TTT-GIL activities focused on microbiology and immunology concepts: one targeted to middle and high school students, and one targeted to advanced undergraduates and masters students.…”