2017
DOI: 10.1016/j.jid.2017.02.976
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Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing

Abstract: The detailed pathophysiology of diabetic foot ulcers is yet to be established and improved treatments are still required. We propose a strategy that directs inflammation, neovascularization, and neoinnervation of diabetic wounds. Aiming to potentiate a relevant secretome for nerve regeneration, stem cells were precultured in hyaluronic acid-based spongy hydrogels under neurogenic/standard media before transplantation into diabetic mice full-thickness wounds. Acellular spongy hydrogels and empty wounds were use… Show more

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Cited by 79 publications
(57 citation statements)
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References 57 publications
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“…In the last decade, skin tissue engineering has evolved dramatically with promising approaches to manage difficult wounds 16 . In fact, preconditioned hydrogels 17 19 , microporous gels 20 or engineered cell sheets 21 , 22 exhibit a tremendous wound healing potential in the preclinical setting. However, the majority of these techniques involves complex in vitro steps and, thus, is not suitable for intraoperative one-step procedures.…”
Section: Discussionmentioning
confidence: 99%
“…In the last decade, skin tissue engineering has evolved dramatically with promising approaches to manage difficult wounds 16 . In fact, preconditioned hydrogels 17 19 , microporous gels 20 or engineered cell sheets 21 , 22 exhibit a tremendous wound healing potential in the preclinical setting. However, the majority of these techniques involves complex in vitro steps and, thus, is not suitable for intraoperative one-step procedures.…”
Section: Discussionmentioning
confidence: 99%
“…Other approaches have combined hyaluronan scaffolds with stem cells derived from keratinocytes and adipose for engineering skin and bone respectively [162,163]. Such engineered tissues can be used as novel ways to promote wound healing as well as for repairing damaged nerve tissues [164][165][166]. Encapsulating stem cells into hyaluronic acid microcarriers is another popular tissue engineering strategy due to its ability to provide a supportive environment for stem cell survival [167,168].…”
Section: Hyaluronanmentioning
confidence: 99%
“…Of the 89 selected articles, there were 54 preclinical studies (60.7%) [ 15 68 ] and 36 clinical studies (40.4%) [ 38 , 69 – 103 ]; one article reported data for both preclinical and clinical studies [ 38 ].…”
Section: Resultsmentioning
confidence: 99%
“…Topical administration was also frequently performed; topical delivery was used in 23 preclinical studies (43%) and five clinical studies (14%). Collagen hydrogels and scaffolds were the most commonly used vehicles to deliver cells [ 15 , 17 , 22 , 29 , 34 , 58 , 64 ]. Various other delivery methods were also used, including a silicon membrane with atelocollagen matrix to deliver murine ADSC [ 52 ], and artificial dermis containing human BM-MSC to treat two DFU patients [ 103 ].…”
Section: Resultsmentioning
confidence: 99%