Stem cell-derived exosomal transcriptomes for wound healing

Chen, Guiling; Chen, Hankun; Zhang, Xiang; Zhu, Wei

doi:10.3389/fsurg.2022.933781

Cited by 3 publications

(3 citation statements)

References 111 publications

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“…In addition, exosomes endow with abundant DNA, miRNA, heat shock protein, angiogenesis factor, and so forth. Among them, exosome‐derived transcriptome, which includes circRNAs, lncRNAs, and miRNAs, is critical in skin repair 24 …”

Section: Introductionmentioning

confidence: 99%

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Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics

Li,

Zhang,

et al. 2023

Cell Proliferation

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How to effectively repair cutaneous wounds and promote skin rejuvenation has always been a challenging issue for clinical medicine and medical aesthetics. Current conventional medicines exhibit several drawbacks, including limited therapeutic effects, prolonged treatment periods, and high costs. As a novel cell‐free therapy, the umbilical cord‐derived mesenchymal stem cell (UCMSC) secretome may offer a promising approach for skin regeneration and rejuvenation. The UCMSC secretome is a collection of all proteins secreted by mesenchymal stem cells, including conditioned media, exosomes, and other substances. The UCMSC secretome has numerous abilities to accelerate acute wound healing, including high fibroblast and keratinocyte proliferative activity, pro‐angiogenesis, anti‐inflammation, anti‐fibrosis, and anti‐oxidative stress. Its impact on the four stages of wound healing is manifested by inducing the haemostasis phase, inhibiting the inflammation phase, promoting the proliferation phase, and regulating the remodelling phase. Furthermore, it is highly effective in the treatment of chronic wounds, alopecia, aging, and skin homeostasis disturbance. This review focuses on the clinical therapies and application prospects of the UCMSC secretome, encompassing its source, culture, separation, identification, storage, and pretreatment. Additionally, a discussion on the dosage, administration route, efficacy, and biosafety in the clinical situation is presented. This review aims to provide scientific support for the mechanistic investigation and clinical utilisation of the UCMSC secretome in wound healing and skin rejuvenation.

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Section: Introductionmentioning

confidence: 99%

“…Among them, exosome‐derived transcriptome, which includes circRNAs, lncRNAs, and miRNAs, is critical in skin repair. 24 …”

Section: Introductionmentioning

confidence: 99%

Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics

Li,

Zhang,

et al. 2023

Cell Proliferation

View full text Add to dashboard Cite

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“…Wound healing includes all of the processes necessary for the recovery of a wound. The study and understanding of wound healing has been divided into three sequential phases, each of which has its own period of time, as well as the involvement of particular tissues and cell lineages [9][10][11][12]. The first is the inflammatory phase.…”

Section: Introductionmentioning

confidence: 99%

Essential Oil of Bursera morelensis Promotes Cell Migration on Fibroblasts: In Vitro Assays

Salas-Oropeza,

Rodriguez-Monroy,

Jimenez-Estrada

et al. 2023

Molecules

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Essential oils (EOs) are complex mixtures of volatile natural compounds. We have extensively studied the EO of Bursera morelensis, which demonstrates antibacterial, antifungal, anti-inflammatory, and wound-healing activities. The objective of this work was to determine the effect of this EO on fibroblast migration in a three-dimensional in vitro model. For the three-dimensional in vitro model, a series of fibrin hydrogel scaffolds (FSs) were built in which fibroblasts were cultured and subsequently stimulated with fibroblast growth factor (FGF) or EO. The results demonstrated that these FSs are appropriate for fibroblast culture, since no decrease in cell viability or changes in cell proliferation were found. The results also showed that this EO promotes cell migration four hours after stimulation, and the formation of cell projections (filopodia) outside the SF was observed. From these results, we confirmed that part of the mechanism of action of the essential oil of B. morelensis during the healing process is the stimulation of fibroblast migration to the wound site.

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Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer

Cheng,

Chen,

et al. 2024

J Cardiothorac Surg

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Stem cell-derived exosomal transcriptomes for wound healing

Cited by 3 publications

References 111 publications

Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics

Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics

Essential Oil of Bursera morelensis Promotes Cell Migration on Fibroblasts: In Vitro Assays

Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer

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