Stem Cell Engraftment and Survival in the Ischemic Heart

Wu, Kai; Mo, Xu Ming; Han, Zhongchao; Zhou, Bin

doi:10.1016/j.athoracsur.2011.07.012

Cited by 85 publications

(77 citation statements)

References 73 publications

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“…19 It is simple and noninvasive, relying on post-AMI physiological signals to target cells towards damaged tissues. 28 Unfortunately, it is inefficient and impractical, as large cell numbers and infusions are necessary for sufficient amounts to reach infarct-related arteries, 29 due to confinement in the microvasculature and losses to other organs. 28,29 Direct intramyocardial injection during coronary artery bypass graft (CABG) surgery easily allows stem cells to be placed into the targeted zone.…”

Section: Modes Of Deliverymentioning

confidence: 99%

“…28 Unfortunately, it is inefficient and impractical, as large cell numbers and infusions are necessary for sufficient amounts to reach infarct-related arteries, 29 due to confinement in the microvasculature and losses to other organs. 28,29 Direct intramyocardial injection during coronary artery bypass graft (CABG) surgery easily allows stem cells to be placed into the targeted zone. 29 Suitable candidates include chronic ischemic HF patients, because chronically infarcted tissue does not release the necessary post-AMI physiological signals to attract and mobilize cells to the infarct zone.…”

Section: Modes Of Deliverymentioning

confidence: 99%

“…29 Suitable candidates include chronic ischemic HF patients, because chronically infarcted tissue does not release the necessary post-AMI physiological signals to attract and mobilize cells to the infarct zone. 19,28 However, only a small amount of cells survive more than three days, 30 because the microenvironment is problematic for cell survival secondary to inflammation and insufficient blood supply. 2,28 This is further complicated by mechanical leakage 2 and arrhythmia potential.…”

Section: Modes Of Deliverymentioning

confidence: 99%

“…19,28 However, only a small amount of cells survive more than three days, 30 because the microenvironment is problematic for cell survival secondary to inflammation and insufficient blood supply. 2,28 This is further complicated by mechanical leakage 2 and arrhythmia potential. 28 Transendocardial injection is similar to the intramyocardial route, but uses a flexible catheter-based percutaneous technique across the aortic valve.…”

Section: Modes Of Deliverymentioning

confidence: 99%

“…2,28 This is further complicated by mechanical leakage 2 and arrhythmia potential. 28 Transendocardial injection is similar to the intramyocardial route, but uses a flexible catheter-based percutaneous technique across the aortic valve. 29 Injecting cells in and around the infarct zone 22 allows greater cell engraftment, 28 while using fewer cells.…”

Section: Modes Of Deliverymentioning

confidence: 99%

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Stem Cell Therapy for Heart Disease

2013

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Coronary artery disease is the leading cause of death in Americans. After myocardial infarction, significant ventricular damage persists despite timely reperfusion and pharmacological management. Treatment is limited, as current modalities do not cure this damage. In the past decade, stem cell therapy has emerged as a promising therapeutic solution to restore myocardial function. Clinical trials have demonstrated safety and beneficial effects in patients suffering from acute myocardial infarction, heart failure, and dilated cardiomyopathy. These benefits include improved ventricular function, increased ejection fraction, and decreased infarct size. Mechanisms of therapy are still not clearly understood. However, it is believed that paracrine factors, including stromal cell-derived factor-1, contribute significantly to stem cell benefits. The purpose of this article is to provide medical professionals with an overview on stem cell therapy for the heart and to discuss potential future directions.

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Section: Modes Of Deliverymentioning

confidence: 99%

Section: Modes Of Deliverymentioning

confidence: 99%

Section: Modes Of Deliverymentioning

confidence: 99%

Section: Modes Of Deliverymentioning

confidence: 99%

Section: Modes Of Deliverymentioning

confidence: 99%

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Stem Cell Therapy for Heart Disease

2013

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An Injectable, Self‐Healing Hydrogel to Repair the Central Nervous System

et al. 2015

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An injectable, self-healing hydrogel (≈1.5 kPa) is developed for healing nerve-system deficits. Neurosphere-like progenitors proliferate in the hydrogel and differentiate into neuron-like cells. In the zebrafish injury model, the central nervous system function is partially rescued by injection of the hydrogel and significantly rescued by injection of the neurosphere-laden hydrogel. The self-healing hydrogel may thus potentially repair the central nervous system.

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Therapeutic Effect of Human Adipose‐Derived Stromal Cells Cluster in Rat Hind‐Limb Ischemia

Park

Kang

et al. 2014

The Anatomical Record

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We investigated whether transplantation of three-dimensional cell masses (3DCM) of human adipose-derived stromal cells (hASCs) cultured on a basic fibroblast growth factor-immobilized substrate improved hind limb functional recovery by stimulating angiogenesis in an immune-competent rat ischemic limb model. In vitro experiments confirmed that cells within 3DCMs differentiate toward the endothelial lineage one day after culture in normal medium. The therapeutic effect of 3DCMs was evaluated by transplanting hASCs, phosphate-buffered saline alone, and the 3DCM into rat ischemic hind limbs. Blood flow was enhanced in the ischemic hind limb in the 3DCM-injected group compared with the other groups. The ratio of human nuclear antigen (HNA) and hVEGF-positive cells was significantly higher in the 3DCM-injected group compared to hASC-injected group. Human VEGF was observed in most HNA-positive cells. Many hCD31 and hSMA-positive cells were observed in vessel-like structures in the 3DCM-injected group. The 3DCM transplantation improved cell retention and angiogenic effects compared with ASC transplantation. These findings suggest that transplantation of 3DCMs may be an effective stem cell therapy for hind limb ischemia.

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Stem Cell Engraftment and Survival in the Ischemic Heart

Cited by 85 publications

References 73 publications

Stem Cell Therapy for Heart Disease

Stem Cell Therapy for Heart Disease

An Injectable, Self‐Healing Hydrogel to Repair the Central Nervous System

Therapeutic Effect of Human Adipose‐Derived Stromal Cells Cluster in Rat Hind‐Limb Ischemia

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