Stem Cell Oriented Exosomes Regulate Cell Proliferation in Hepatoma Carcinoma

Karima, Gul; Shin, Kyusoon; Jeong, Jae‐Weon; Choi, Dongho; Hwang, Kyung‐Gyun; Hong, Jong Wook

doi:10.1007/s12257-022-0238-y

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…To examine the role of NLF-derived exosomes from 5XFAD animals, FAST was used to collect intact exosomes from limited amounts of nasal fluid with high yield and purity [ 17 , 18 , 19 ] ( Figure 1 A). Under consistent temperature control, we determined the size distribution of particles isolated from NLF using nanoparticle tracking analysis ( Figure 1 B).…”

Section: Resultsmentioning

confidence: 99%

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Alteration of Neural Network and Hippocampal Slice Activation through Exosomes Derived from 5XFAD Nasal Lavage Fluid

Kim,

Jeon,

Ganbat

et al. 2023

IJMS

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Exosomes, key mediators of intercellular transmission of pathogenic proteins, such as amyloid-beta and tau, significantly influence the progression and exacerbation of Alzheimer’s disease (AD) pathology. Present in a variety of biological fluids, including cerebrospinal fluid, blood, saliva, and nasal lavage fluid (NLF), exosomes underscore their potential as integral mediators of AD pathology. By serving as vehicles for disease-specific molecules, exosomes could unveil valuable insights into disease identification and progression. This study emphasizes the imperative to investigate the impacts of exosomes on neural networks to enhance our comprehension of intracerebral neuronal communication and its implications for neurological disorders like AD. After harvesting exosomes derived from NLF of 5XFAD mice, we utilized a high-density multielectrode array (HD-MEA) system, the novel technology enabling concurrent recordings from thousands of neurons in primary cortical neuron cultures and organotypic hippocampal slices. The ensuing results revealed a surge in neuronal firing rates and disoriented neural connectivity, reflecting the effects provoked by pathological amyloid-beta oligomer treatment. The local field potentials in the exosome-treated hippocampal brain slices also exhibited aberrant rhythmicity, along with an elevated level of current source density. While this research is an initial exploration, it highlights the potential of exosomes in modulating neural networks under AD conditions and endorses the HD-MEA as an efficacious tool for exosome studies.

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Section: Resultsmentioning

confidence: 99%

“…Nasal-derived exosome isolation was performed as described previously [ 17 , 18 , 19 ], with minor modifications. In brief, nasal lavage fluid harvested from the mouse model was filtered through a 0.2 µm syringe filter (Sartorius, Goettingen, Germany) to remove aggregates.…”

Section: Methodsmentioning

confidence: 99%

Alteration of Neural Network and Hippocampal Slice Activation through Exosomes Derived from 5XFAD Nasal Lavage Fluid

Kim,

Jeon,

Ganbat

et al. 2023

IJMS

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“…34 The development of nanotechnology has contributed to advances in healthcare and medicine, holding ever greater promise. 35–37 In particular, nanomaterials have been utilized to substantially improve diagnostics as well as treatments. In the latter case, this is achieved by overcoming the drawbacks of conventional drug delivery systems.…”

Section: Nanotechnology For Ad Treatment and The Bbbmentioning

confidence: 99%