Stem cell technology and engineering for cancer treatment

Truong, Sinh Nguyen; Pham, Phuc Van

doi:10.7603/s40730-015-0013-1

Cited by 2 publications

(1 citation statement)

References 77 publications

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“…In addition, the duration, frequency, and the number of chemotherapy or radiation therapy cycles produce negative side effects that tend to gradually get worse over time. Based on these findings, researchers have developed further cancer therapies to improve the effectiveness of treatments while reducing undesired side effects, such as immunotherapy [ 12 , 13 ], hormone therapy [ 14 ], gene therapy [ 15 , 16 ], cryotherapy [ 17 ], targeted cancer therapies [ 18 , 19 ], stem cell transplant [ 20 , 21 ], thermal therapy [ 22 , 23 ], and photodynamic therapy [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

et al. 2018

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Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactive oxygen species (ROS), leading to cellular damage. One of the drawbacks of PSs is their lack of solubility in water and body tissue fluids, thereby causing low bioavailability, drug-delivery efficiency, therapeutic efficacy, and ROS production. To improve the water-solubility and/or drug delivery of PSs, using cyclodextrins (CDs) is an interesting strategy. This review describes the in vitro or/and in vivo use of natural and derived CDs to improve antitumoral PDT efficiency in aqueous media. To achieve these goals, three types of binding modes of PSs with CDs are developed: non-covalent CD–PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies. This review is divided into three parts: (1) non-covalent CD-PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies, (2) incorporating CD–PS systems into hybrid nanoparticles (NPs) using up-converting or other types of NPs, and (3) CDs with fullerenes as PSs.

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