Stem Cell Therapy for Erectile Dysfunction: Progress and Future Directions

Albersen, Maarten; Weyne, Emmanuel; Bivalacqua, Trinity J.

doi:10.1002/smrj.5

Cited by 23 publications

(17 citation statements)

References 57 publications

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“…The treatment seems safe and preliminary indicators of effectiveness were present in a small number of treated patients 209 . Furthermore, a plethora of studies have investigated the preclinical administration of stem cells in animal models of erectile dysfunction related to ageing, type 1 and type 2 diabetes, cavernous nerve injury, Peyronie disease and even penile trauma 210 . Researchers have generally reached a consensus that the results of these studies, mainly using mesenchymal stem cells from the bone marrow and adipose tissue, show this to be a promising approach 211 .…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction

Yafi

Jenkins

Albersen

et al. 2016

Nat Rev Dis Primers

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Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man’s quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner’s sexual experience and the couple’s quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.

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Section: Discussionmentioning

confidence: 99%

Erectile dysfunction

Yafi

Jenkins

Albersen

et al. 2016

Nat Rev Dis Primers

Self Cite

604

500

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show abstract

“…The use of stem cells for the treatment of ED represents an exciting new field, which still requires extensive basic research and human trials in diverse ED patient populations in order to define its role in the treatment of ED [109]. Preclinical studies have shown that these cells may reverse pathophysiological changes leading to ED, for example, following cavernous nerve injury and in Peyronie's disease, diabetes, aging, and hyperlipidemia.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Preclinical studies have shown that these cells may reverse pathophysiological changes leading to ED, for example, following cavernous nerve injury and in Peyronie's disease, diabetes, aging, and hyperlipidemia. Overall, these studies have shown beneficial effects, while evidence on the mechanisms of action of stem cell therapy still varies between studies [109]. …”

Section: Future Perspectivesmentioning

confidence: 99%

Erectile Dysfunction in the Elderly: An Old Widespread Issue with Novel Treatment Perspectives

Gareri¹,

Castagna

Francomano

et al. 2014

International Journal of Endocrinology

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Erectile dysfunction (ED) is one of the most common chronic diseases affecting men and its prevalence increases with aging. It is also the most frequently diagnosed sexual dysfunction in the older male population. A number of different diseases potentially worsening sexual function may occur in elderly people, together with polypharmacy. Related causes of ED are variable and can include arterial, neurogenic, hormonal, cavernosal, iatrogenic, and psychogenic causes. The aim of the present review was to examine the main aspects of erectile dysfunction going through epidemiology and pathophysiology and revise most of ED in elderly disabled men and in those affected with psychiatric disorders. Lastly we tried to focus on the main aspects of nonpharmacological and pharmacological treatments of ED and the recreational use in the elderly. Phosphodiesterase-5 inhibitors (PDE5-I) are commonly used for on-demand or chronic treatment of ED. It is widely known that PDE5-I have lower response rates in older men than in younger patients, but they have the advantages of ease of use and excellent safety profile, also in the elderly. The old and new PDE5-I as well as the alternative treatments for ED are extensively discussed.

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“…This is potentially advantageous for localization of compounds or stem cells to a specific region. The goal of this study by Lin et al [23] was to investigate if NanoShuttle magnetic nanoparticle delivery of stem cells injected into the corpora cavernosa, could maintain stem cells longer in the corpora cavernosa, so as to further improve erectile dysfunction in a rat CN crush model, over conventional stem cell delivery. The significance of localizing stem cells is that most stem cells, when injected, travel to the bone marrow and other places in the body (cavernous nerve), thus exerting paracrine effects rather than direct effects on the corporal tissue.…”

Section: Resultsmentioning

confidence: 99%

“…The significance of localizing stem cells is that most stem cells, when injected, travel to the bone marrow and other places in the body (cavernous nerve), thus exerting paracrine effects rather than direct effects on the corporal tissue. For detailed discussion of stem cell in rat models and potential paracrine effects, see Albersen et al 2016 [23]. NanoShuttle is a biocompatible magnetic nano-particle assembly (approximately 50nm) consisting of gold nanoparticles, iron oxide and poly-L-lysine.…”

Section: Resultsmentioning

confidence: 99%

Role of Nanotechnology in Erectile Dysfunction Treatment

Wang

Podlasek

2017

The Journal of Sexual Medicine

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Introduction The biological importance of nanotechnology based delivery vehicles for in vivo tissue regeneration is gaining acceptance by the medical community, however its relevance and incorporation into the treatment of sexual dysfunction is evolving and has not been well evaluated. Aim This article aims to provide scientific evidence examining the use of state of the art nanotechnology based delivery methodology in the treatment of erectile dysfunction (ED) in animal models and in patients. Methods In this review, we assessed current basic science literature examining the role of nanotechnology based delivery vehicles in the development of potential erectile dysfunction therapies. Results There are four primary areas where nanotechnology has been applied for ED treatment; 1) Topical delivery of drugs for on demand erectile function, 2) Injectable gels into the penis to prevent morphology changes post prostatectomy, 3) Hydrogels to promote CN regeneration/neuroprotection, and 4) Encapsulation of drugs to increase erectile function (primarily of PDE5 inhibitors). Conclusions Basic science studies provide evidence for a significant and evolving role of nanotechnology in the development of therapies for erectile dysfunction and suggest that properly administered nano based therapies may be potentially advantageous for treating male sexual dysfunction.

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Stem Cell Therapy for Erectile Dysfunction: Progress and Future Directions

Cited by 23 publications

References 57 publications

Erectile dysfunction

Erectile dysfunction

Erectile Dysfunction in the Elderly: An Old Widespread Issue with Novel Treatment Perspectives

Role of Nanotechnology in Erectile Dysfunction Treatment

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