Stem cell therapy for glaucoma: Science or snake oil?

Sun, Yi; Williams, Alice; Waisbourd, Michael; Iacovitti, Lorraine; Katz, L. Jay

doi:10.1016/j.survophthal.2014.07.001

Cited by 31 publications

(24 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…tRGC survival was observed in both Lip A and Lip C groups (Figure 6 and Supplementary Figure S8) 4 weeks after transplantation, showing a longer survival time for tRGCs compared to previous reports on transplanted cells. 88−90 …”

Section: Resultsmentioning

confidence: 99%

Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage

et al. 2018

View full text Add to dashboard Cite

A common event in optic neuropathies is the loss of axons and death of retinal ganglion cells (RGCs) resulting in irreversible blindness. Mammalian target of rapamycin (mTOR) signaling pathway agonists have been shown to foster axon regeneration and RGC survival in animal models of optic nerve damage. However, many challenges remain in developing therapies that exploit cell growth and tissue remodeling including (i) activating/inhibiting cell pathways synergistically, (ii) avoiding tumorigenesis, and (iii) ensuring appropriate physiological tissue function. These challenges are further exacerbated by the need to overcome ocular physiological barriers and clearance mechanisms. Here we present liposomes loaded with multiple mTOR pathway stimulating biologics designed to enhance neuroprotection after retina damage. Liposomes were loaded with ciliary neurotrophic factor, insulin-like growth factor 1, a lipopeptide N-fragment osteopontin mimic, and lipopeptide phosphatase tension homologue inhibitors for either the ATP domain or the c-terminal tail. In a mouse model of N-methyl-d-aspartic acid induced RGC death, a single intravitreal administration of liposomes reduced both RGC death and loss of retina electrophysiological function. Furthermore, combining liposomes with transplantation of induced pluripotent stem cell derived RGCs led to an improved electrophysiological outcome in mice. The results presented here show that liposomes carrying multiple signaling pathway modulators can facilitate neuroprotection and transplant electrophysiological outcome.

show abstract

Section: Resultsmentioning

confidence: 99%

Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, this strategy cannot always prevent disease progression and some glaucoma patients may not have increased IOP. To improve management of glaucoma, stop the irreversible disease progression and restore vision in these patients, researchers have begun to consider using stem cell-derived RGCs to rebuild the visual perception pathway and restore sight (Sluch and Zack, 2014;Sun et al, 2015).…”

Section: Glaucoma and Rgc Transplantationmentioning

confidence: 99%

Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells

2017

View full text Add to dashboard Cite

Retinal degenerative diseases are the leading causes of blindness worldwide. Replacing lost retinal cells via stem cell-based therapies is an exciting, rapidly advancing area of translational research that has already entered the clinic. Here, we review the status of these clinical efforts for several significant retinal diseases, describe the challenges involved and discuss how basic developmental studies have contributed to and are needed to advance clinical goals.

show abstract

“…MSCs can be derived from bone marrow, adipose tissue, human umbilical cord blood (UCB), and other tissues (Sun, Williams, Waisbourd, Iacovitti, & Katz, 2015). Although there is some controversy, there are indications that these cells have the potential to differentiate into various other types of cells, including neural cells.…”

Section: Stem Cell Sourcesmentioning

confidence: 99%