2014
DOI: 10.1007/s12016-014-8445-8
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Stem Cell Therapy in Autoimmune Rheumatic Diseases: a Comprehensive Review

Abstract: The clinical management of autoimmune rheumatic diseases (ARD) has undergone significant changes in the last few decades, leading to remarkable improvements in clinical outcomes of many patients with mild to moderate ARD. On the other hand, severe refractory ARD patients often have high morbidity and mortality. Extensive basic research and clinical evidence has opened the door to new encouraging perspectives, such as the establishment of a role of stem cell transplantation (SCT) in the strategic management of … Show more

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Cited by 13 publications
(5 citation statements)
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“…TLR2 is activated upon recognition of PAMPs, which bind to the intracellular adaptor protein MyD88 to activate a number of signaling pathways that lead to the expression of pro-inflammatory cytokines (24). To investigate if OV could inhibit TLR2 signaling by interfering with TLR2-MyD88 interaction, a Co-IP assay was performed with lysates from MPC5 cells with or without OV treatment and LPS stimulation using an anti-MyD88 antibody.…”
Section: Resultsmentioning
confidence: 99%
“…TLR2 is activated upon recognition of PAMPs, which bind to the intracellular adaptor protein MyD88 to activate a number of signaling pathways that lead to the expression of pro-inflammatory cytokines (24). To investigate if OV could inhibit TLR2 signaling by interfering with TLR2-MyD88 interaction, a Co-IP assay was performed with lysates from MPC5 cells with or without OV treatment and LPS stimulation using an anti-MyD88 antibody.…”
Section: Resultsmentioning
confidence: 99%
“…Mesenchymal stem cells (MSCs) represent an optimal tool for tissue regeneration in a clinical setting due to their multipotency, being able to differentiate into various cells (bone, cartilage, fat, muscle, and tendon) under appropriate conditions. This particular property together with their low immunogenicity and the ability to secrete bioactive factors (cytokines, chemokines, and growth factors) in response to local microenvironmental cues, makes them an ideal candidate for the treatment of different pathologies (Dalal, Gandy, & Domen, ; Gnecchi, Danieli, & Cervio, ; Liu, Shu, Kenny, Chang, & Leung, ; Park, Kim, Lee, Park, & An, ).…”
Section: Introductionmentioning
confidence: 99%
“…Supported by animal models of antigen‐induced autoimmunity, the primary goal of this therapeutic approach is to achieve drug‐free remission by elimination of the disease‐mediating immune cells and re‐establishment of immune regulation, thereby restoring self‐tolerance. Numerous phase I‐II studies have tested autologous HSCT in diseases, such as multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and juvenile idiopathic arthritis [reviewed in (Liu et al , ; Openshaw et al , )]. Most commonly, the graft is T‐cell depleted, because lympho‐depletion of disease‐causing cells is vital.…”
Section: Future Directionsmentioning
confidence: 99%