Stem-cell therapy in stress urinary incontinence: A review

Ding, Dah-Ching; Li, Pei-Chen

doi:10.4103/tcmj.tcmj_145_22

Cited by 4 publications

(2 citation statements)

References 77 publications

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“…These sources include adult and fetal tissues and human embryonic stem cells (hESCs). Although clinical trials with stem cell therapy have been reported in erectile dysfunction, 10 stress urinary incontinence, 11 and detrusor underactivity, 12 none have been conducted for IC/BPS in the field of urology.…”

Section: Why Is Stem Cell Therapy a Potential Candidate For Interstit...mentioning

confidence: 99%

Stem cell therapy for interstitial cystitis/bladder pain syndrome

Shin,

Park,

Ryu

et al. 2024

LUTS

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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disease with limited treatment options. Current multidisciplinary approach targeting bladder inflammation and urothelial dysfunction has limited durable effect that major surgery is ultimately required for both Hunner and non‐Hunner type IC. Various investigational attempts are underway to avoid such operations and preserve the urinary bladder. Stem cell therapy is a fascinating option for treating chronic illnesses. Stem cells can self‐renew, restore damaged tissue, and have paracrine effects. The therapeutic efficacy and safety of stem cell therapy have been demonstrated in numerous preclinical models, primarily chemically induced cystitis rat models. Only one clinical trial (phase 1 study) has investigated the safety of human embryonic stem cell‐derived mesenchymal stem cells in three Hunner‐type IC patients. Under general anesthesia, participants underwent cystoscopic submucosal stem cell injection (2.0 × 107 stem cells/5 mL). No safety issues were reported up to 12 months of follow‐up and long‐term follow‐up (up to 3 years). Although there were variations in therapeutic response, all patients reported significant improvement in pain at 1 month postoperatively. One patient underwent fulguration of the Hunner lesion after the trial, but others reported an overall improvement in pain. The analysis on phase 1/2a trial which had several modifications in protocol is currently ongoing. Despite several limitations that need to be overcome, stem cell therapy could be a potential therapeutic option for treating IC/BPS. Clinical outcome on phase 1/2a trial is important and might provide more insight into the clinical application of stem cell therapy for IC/BPS.

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Section: Why Is Stem Cell Therapy a Potential Candidate For Interstit...mentioning

confidence: 99%

Stem cell therapy for interstitial cystitis/bladder pain syndrome

Shin,

Park,

Ryu

et al. 2024

LUTS

View full text Add to dashboard Cite

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“…Nevertheless, an optimal treatment for all types of incontinence has not been established. 1,2 Continence and micturition are achieved by a complex interplay of anatomical structures such as the urethral sphincter, detrusor, bladder neck, urethral smooth muscle, nerves, vascular plexus and the surrounding tissue support. There is an active and passive component contributing to intraurethral pressure.…”

Section: Introductionmentioning

confidence: 99%

The Systematic Review of Stem Cell Therapy for Stress Urinary Incontinence

Nanda Satya Pratama,

Himawan

2024

JARMHS

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The aim: This study aims to show stem cell therapy for stress urinary incontinence. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up to date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: In the PubMed database the results of our search brought up 133 articles, whereas the results of our search on SagePub brought up 54 articles. The results of the search conducted for the last year of 2013 yielded a total 89 articles for PubMed and 41 articles for SagePub. The result from title screening, a total 9 articles for PubMed and 15 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria. Conclusion: Comprehensive comparisons between stem cell-based approaches and existing therapies are a prerequisite to rendering stem cell treatment as the predominant strategy for treating intractable urological disorders in the future.

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Comparative Analysis of the Efficacy of Different Surgical Modalities for the Treatment of Female Stress Urinary Incontinence: A Multicenter Retrospective Study

Jiang,

Yuan

2024

IJWH

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Objective To compare the efficacy of autologous fascial retropubic midurethral sling, anterior vaginal wall epithelial flap midurethral suspension, tension-free vaginal tape-obturator and adjustable urethral suspension with a single incision for the treatment of female stress urinary incontinence. Materials and Methods A total of 243 SUI patients who were admitted to Minda Hospital of Hubei Minzu University, were chosen and split into four groups based on various surgical techniques: the AFS group (59 cases), TVT-O group (61 cases), epithelial flap group (62 cases) and ASIS group (61 cases). A comparison of four patient groups’ quality-of-life scores, urodynamic indices, urethral structure-related indices before and a year after treatment, complication rates and perioperative-related indices. Results There was no discernible difference in the treatment outcomes among the four groups(P>0.05). However, the ASIS group exhibited significantly reduced intraoperative hemorrhage, hospitalization duration and operative time compared to the mucosal flap and TVT-O groups(P<0.05). Both the TVT-O and ASIS groups demonstrated significantly higher hospitalization expenditures than the mucosal flap and AFS groups (P<0.05). No significant differences were observed in postoperative indwelling catheterization, IIQ-7 and I-QOL ratings, urodynamic indices or urethral structure-related indexes across the four patient groups(P>0.05). The TVT-O group showed a significantly higher incidence of postoperative medial thigh pain compared to the AFS, mucosal flap, and ASIS groups(P<0.05). Similarly, the AFS group had a significantly greater incidence of postoperative urine retention compared to the mucosal flap, TVT-O, and ASIS groups(P<0.05). Conclusion While all four surgical techniques demonstrated good efficacy and improved patients’ quality of life, our study suggests that TVT-O had a significantly higher incidence of post-treatment medial thigh pain and ASIS may be a safer and less problematic surgical approach for the treatment of female SUI. This has important therapeutic implications.

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Stem-cell therapy in stress urinary incontinence: A review

Cited by 4 publications

References 77 publications

Stem cell therapy for interstitial cystitis/bladder pain syndrome

Stem cell therapy for interstitial cystitis/bladder pain syndrome

The Systematic Review of Stem Cell Therapy for Stress Urinary Incontinence

Comparative Analysis of the Efficacy of Different Surgical Modalities for the Treatment of Female Stress Urinary Incontinence: A Multicenter Retrospective Study

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