Stem Cell Therapy

Graffmann, Nina; Spitzhorn, Lucas‐Sebastian; Martins, Soraia; Rahman, Shaifur; Nguyen, Lisa; Adjaye, James

doi:10.1007/978-3-319-56637-5_72-1

Drug Discovery and Evaluation: Methods in Clinical Pharmacology 2019

DOI: 10.1007/978-3-319-56637-5_72-1

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Stem Cell Therapy

Nina Graffmann¹,

Lucas‐Sebastian Spitzhorn²,

Soraia Martins³

et al.

Abstract: Stem cell therapy and regenerative medicine have a tremendous potential for the treatment of a wide variety of currently fatal diseases. So far, routine stem cell based therapies are limited to the treatment of hematologic and dermatologic malignancies, but the field is continuously evolving. One research focus lies on mesenchymal stem cells (MSCs) which have an immunomodulatory potential and support regenerative processes throughout the body. Pluripotent stem cells, on the other hand, can be differentiated in… Show more

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2022

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Cited by 1 publication

References 109 publications

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MicroRNAs: Crucial Players in the Differentiation of Human Pluripotent and Multipotent Stem Cells into Functional Hepatocyte-Like Cells

Yuan

et al. 2022

CSCR

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: Hepatic disease negatively impacts liver function and metabolism. Primary human hepatocytes are the gold standard for the prediction and successful treatment of liver disease. However, the sources of hepatocytes for drug toxicity testing and disease modeling are limited. To overcome this issue, pluripotent stem cells (PSCs) have emerged as an alternative strategy for liver disease therapy. Human PSCs, including embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) can self-renew and give rise to all cells of the body. Human PSCs are attractive cell sources for regenerative medicine, tissue engineering, drug discovery, and developmental studies. Several recent studies have shown that mesenchymal stem cells (MSCs) can also differentiate (or trans-differentiate) into hepatocytes. Differentiation of human PSCs and MSCs into functional hepatocyte-like cells (HLCs) opens new strategies to study genetic diseases, hepatotoxicity, infection of hepatotropic viruses, and analyze hepatic biology. Numerous in vitro and in vivo differentiation protocols have been established to obtain human PSCs/MSCs-derived HLCs and mimic their characteristics. It was recently discovered that microRNAs (miRNAs) play a critical role in controlling the ectopic expression of transcription factors and governing the hepatocyte differentiation of human PSCs and MSCs. In this review, we focused on the role of miRNAs in the differentiation of human PSCs and MSCs into hepatocytes.

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MicroRNAs: Crucial Players in the Differentiation of Human Pluripotent and Multipotent Stem Cells into Functional Hepatocyte-Like Cells

Yuan

et al. 2022

CSCR

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Stem Cell Therapy

Cited by 1 publication

References 109 publications

MicroRNAs: Crucial Players in the Differentiation of Human Pluripotent and Multipotent Stem Cells into Functional Hepatocyte-Like Cells

MicroRNAs: Crucial Players in the Differentiation of Human Pluripotent and Multipotent Stem Cells into Functional Hepatocyte-Like Cells

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