Stem Cell Transplantation for the Treatment of Peripheral Arterial Disease

Παπάνας, Νικόλαος

doi:10.5772/20138

Stem Cells in Clinic and Research 2011

DOI: 10.5772/20138

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Stem Cell Transplantation for the Treatment of Peripheral Arterial Disease

Νικόλαος Παπάνας¹

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2012

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Cited by 1 publication

References 73 publications

(131 reference statements)

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Advances in the Topical Treatment of Diabetic Foot Ulcers

Παπάνας

Eleftheriadou²,

Tentolouris³

et al. 2012

CDR

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The diabetic foot remains a major cause of morbidity worldwide. Even though considerable progress has been achieved over the past years, there is still an urgent need for improvement. While established therapeutic modalities (revascularization, casting and debridement) remain the mainstay of management, there is, therefore, continuous development of new treatment options. This review provides an outlook of advances in topical treatment, including bioengineered skin substitutes (such as Dermagraft, Apligraf, HYAFF, OASIS and Graftjacket), extracellular matrix proteins (such as Hyalofill and E-matrix), as well as miscellaneous further therapeutic adjuncts. Although promising, new therapies should not, for the time being, constitute the basis of management, since clinical experience has not yet confirmed their effectiveness in hard-to-heal diabetic foot ulcers. Furthermore, their cost-effectiveness merits further investigation. Instead, they should only be considered in combination with established treatments or be attempted when these have not been successful. Moreover, we should not be oblivious to the fact that established and emerging treatments need to be practised in the setting of multidisciplinary foot clinics to reduce the number of amputations.

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Advances in the Topical Treatment of Diabetic Foot Ulcers

Παπάνας

Eleftheriadou²,

Tentolouris³

et al. 2012

CDR

View full text Add to dashboard Cite

show abstract

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Stem Cell Transplantation for the Treatment of Peripheral Arterial Disease

Cited by 1 publication

References 73 publications

Advances in the Topical Treatment of Diabetic Foot Ulcers

Advances in the Topical Treatment of Diabetic Foot Ulcers

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