Stem cell transplantation therapy in Parkinson’s disease

Fu, Mu Hui; Li, Chia Ling; Lin, Hsiu Lien; Chen, Pei Chun; Calkins, Marcus J.; Chang, Yu Fan; Cheng, Pei Hsun; Yang, Su–Hua

doi:10.1186/s40064-015-1400-1

Cited by 39 publications

(32 citation statements)

References 105 publications

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“…Therefore, new strategies based on the use of stem cells, such as neural stem cells (NSCs), have emerged as an alternative therapy for PD . NSCs are multipotent stem cells isolated from fetal and adult nervous system tissues with the ability to self‐renew and differentiate into specialized functional neurons and glial cells, making them an interesting source of cells for neuronal repair after injury or disease . In fact, different reports have already shown that the transplantation of NSCs display therapeutic effects, such as the capacity to protect and regenerate damaged DA neurons, as well as the potential to improve function in animal models of PD.…”

Section: Introductionmentioning

confidence: 99%

Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease

Mendes-Pinheiro

Teixeira

Anjo

et al. 2018

Stem Cells Translational Medicine

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Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results from the death of dopamine (DA) neurons. Over recent years, differentiated or undifferentiated neural stem cells (NSCs) transplantation has been widely used as a means of cell replacement therapy. However, compelling evidence has brought attention to the array of bioactive molecules produced by stem cells, defined as secretome. As described in the literature, other cell populations have a high‐neurotrophic activity, but little is known about NSCs. Moreover, the exploration of the stem cell secretome is only in its initial stages, particularly as applied to neurodegenerative diseases. Thus, we have characterized the secretome of human neural progenitor cells (hNPCs) through proteomic analysis and investigated its effects in a 6‐hydroxidopamine (6‐OHDA) rat model of PD in comparison with undifferentiated hNPCs transplantation. Results revealed that the injection of hNPCs secretome potentiated the histological recovery of DA neurons when compared to the untreated group 6‐OHDA and those transplanted with cells (hNPCs), thereby supporting the functional motor amelioration of 6‐OHDA PD animals. Additionally, hNPCs secretome proteomic characterization has revealed that these cells have the capacity to secrete a wide range of important molecules with neuroregulatory actions, which are most likely support the effects observed. Overall, we have concluded that the use of hNPCs secretome partially modulate DA neurons cell survival and ameliorate PD animals’ motor deficits, disclosing improved results when compared to cell transplantation approaches, indicating that the secretome itself could represent a route for new therapeutic options for PD regenerative medicine. stem cells translational medicine 2018;7:829–838

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Section: Introductionmentioning

confidence: 99%

Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease

Mendes-Pinheiro

Teixeira

Anjo

et al. 2018

Stem Cells Translational Medicine

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“…Additionally, these cells have been recognized for their ability to migrate to the wound area in order to integrate as neuroglia into preexisting circuits, ultimately helping to repair cellular damage. These findings have been clinically correlated with an improvement in both motor and cognitive performances in rodent and primate models of neurodegenerative syndromes such as Alzheimer's and Parkinson's disease (Berrío Sánchez, Cucarián Hurtado, & de Oliveira, ; Fu et al, ; Kikuchi et al, ; McGinley et al, 2018; Moon et al, ; Yang, Zhang, Oldenburg, Ayala, & Zhang, ). Similar advantageous effects have been reported in certain clinical trials including patients with either traumatic central nervous system injuries, neurodegenerative pathologies, or peripheral nerve damage, with these effects apparently more pronounced in terms of restoration of locomotor function compared to cognitive performance (Song et al, ; Volkman & Offen, ).…”

Section: Introductionmentioning

confidence: 92%

“…Cell‐based therapies have been proposed as promising therapeutic approaches, both to functional recovery in damaged nervous tissue and to restrain the progress of endorse PD (Fu et al, ). Approximately 30 years ago, stem cells were being collected from bone marrow and used for the pioneering treatment of bone marrow transplantation to treat blood diseases (de la Morena & Gatti, ).…”

Section: Introductionmentioning

confidence: 99%

Physical exercise and human adipose‐derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease

Cucarián

Berrío

Rodrigues

et al. 2019

J of Neuroscience Research

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Parkinson's disease (PD) is a disabling and highly costly neurodegenerative condition with worldwide prevalence. Despite advances in treatments that slow progression and minimize locomotor impairments, its clinical management is still a challenge. Previous preclinical studies, using mesenchymal stem cell (MSC) transplantation and isolated physical exercise (EX), reported beneficial results for treatment of PD. Therefore, this experimental randomized study aimed to elucidate the therapeutic potential of combined therapy using adipose-derived human MSCs (ADSCs) grafted into the striatum in conjunction with aerobic treadmill training, specifically in terms of locomotor performance in a unilateral PD rat model induced by 6-hydroxydopamine (6-OHDA). Forty-one male Wistar rats were categorized into five groups in accordance with the type of treatment to which they were subjected (Sham, 6-OHDA − injury, 6-OHDA + exercise, 6-OHDA + cells, and 6-OHDA + combined). Subsequently, dopaminergic depletion was assessed by the methylphenidate challenge and the specified therapeutic intervention was conducted in each group. The foot fault task was performed at the end of the experiment to serve as an assessment of motor skills. The results showed that despite disturbances in motor balance and coordination, locomotor dysfunction was ameliorated in all treatment categories in comparison to the injury group (sign test, p < 0.001, effect size: 0.71). The exercise alone and combined groups were the categories that exhibited the best recovery in terms of movement performance (p < 0.001). Overall, this study confirms that exercise is a powerful option to improve motor function and a promising adjuvant intervention for stem cell transplantation in the treatment of PD motor symptoms.

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“…Rigidity, resting tremor and bradykinesia are the major symptoms which make PD the most common movement disorder of the world affecting individuals post 65 years of age (Fu et al, 2015). Mechanistic and pathophysiological studies have given us a deep understanding of the disease.…”

Section: Parkinson's Disease (Pd)mentioning

confidence: 99%

Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases

Singh

Srivastav

Srivastava

et al. 2016

Front. Mol. Biosci.

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Neurodegeneration and neurodegenerative disorders have been a global health issue affecting the aging population worldwide. Recent advances in stem cell biology have changed the current face of neurodegenerative disease modeling, diagnosis, and transplantation therapeutics. Stem cells also serve the purpose of a simple in-vitro tool for screening therapeutic drugs and chemicals. We present the application of stem cells and induced pluripotent stem cells (iPSCs) in the field of neurodegeneration and address the issues of diagnosis, modeling, and therapeutic transplantation strategies for the most prevalent neurodegenerative disorders. We have discussed the progress made in the last decade and have largely focused on the various applications of stem cells in the neurodegenerative research arena.

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Stem cell transplantation therapy in Parkinson’s disease

Cited by 39 publications

References 105 publications

Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease

Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease

Physical exercise and human adipose‐derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease

Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases

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