Stem Cell Treatments for Neurodegenerative Diseases: Challenges from a science, Business and Healthcare Perspective

Rosemann, Achim

doi:10.2217/nmt.15.2

Cited by 9 publications

(4 citation statements)

References 9 publications

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Section: Introductionmentioning

confidence: 99%

“…Emerging studies have suggested that stem cell‐based therapies may be a new intervention for neurodegenerative diseases . The success of stem cell therapy may largely depend on high‐efficient supply of desired functional cell types . However, the limited supply of required stem cells, low‐efficient conversion technologies, unstable genetic manipulation, and complex ethical controversies are the main challenges in the field .…”

Section: Introductionmentioning

confidence: 99%

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Myt1l induced direct reprogramming of pericytes into cholinergic neurons

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myt1l induced direct reprogramming of pericytes into cholinergic neurons

et al. 2018

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“…Therefore, the development and production cost of this technologies will be reflected on the therapeutical option final price. Thereafter, is expected that the fees for stem cell-based therapy for neurodegenerative diseases will be between USD 30.000 and USD 100.000 for each patient [113]. These analyses reasonably prospect that, for now, these therapeutic approaches will be remain unavailable for a large number of patients but, with the progressive improvement of technological process, drug development costs will be reduced, allowing an increased number of subjects the access to these promising therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases?

Bonaventura

Munafò

Bellanca

et al. 2021

Cells

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Neurodegenerative diseases are characterized by the progressive loss of structure and/or function of both neurons and glial cells, leading to different degrees of pathology and loss of cognition. The hypothesis of circuit reconstruction in the damaged brain via direct cell replacement has been pursued extensively so far. In this context, stem cells represent a useful option since they provide tissue restoration through the substitution of damaged neuronal cells with exogenous stem cells and create a neuro-protective environment through the release of bioactive molecules for healthy neurons, as well. These peculiar properties of stem cells are opening to potential therapeutic strategies for the treatment of severe neurodegenerative disorders, for which the absence of effective treatment options leads to an increasingly socio-economic burden. Currently, the introduction of new technologies in the field of stem cells and the implementation of alternative cell tissues sources are pointing to exciting frontiers in this area of research. Here, we provide an update of the current knowledge about source and administration routes of stem cells, and review light and shadows of cells replacement therapy for the treatment of the three main neurodegenerative disorders (Amyotrophic lateral sclerosis, Parkinson’s, and Alzheimer’s disease).

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“…A possible solution proposed by Yamanaka is the creation of human stem cell banks for therapeutic use, where a standard matrix of different cell lines containing the main HLA types, are available and can be tolerated by 80% of the population. Thus it is intended to reduce the deriving and testing time in each patient, alleviate histocompatibility problems and reduce therapy costs [88] (Table 2). Another important problem to be solved in hiPS cells is the observation of mutations in some of the cell lines, which were not present in the original patient fibroblasts; probably due to the reprogramming process itself [89].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Treatment of Parkinson’s disease using human stem cells

Palmer¹,

Coronel²,

Liste³

2016

J Stem Cell Res Med

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The progressive loss of dopamine neurons (DAn) in the substantia nigra is the main characteristic of Parkinson's disease (PD), the second most common neurodegenerative disorder causing several motor symptoms. Current treatment options for PD are available to help relieve primary motor symptoms, but their longterm effectiveness is limited and they do not stop neuronal degeneration. For this reason, alternative treatment options are being sought in the form of cell replacement therapies (CRT). Several open label clinical trials involving the intrastriatal transplantation of human fetal ventral mesencephalic tissue (hfVM) has provided proof of concept that CRT could be beneficial for some patients, providing relief of motor symptoms. However, the lack of availability of tissue and ethical issues limit the clinical use on a large scale of this strategy, therefore being sought alternative cell sources, based on the use of human stem cells.In this review we provide an overview of the different types of human stem cells currently available, mainly multipotent and pluripotent stem cells, their advantages and disadvantages from an experimental and clinical point of view, and how they are being developed clinically for PD treatment.

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Stem Cell Treatments for Neurodegenerative Diseases: Challenges from a science, Business and Healthcare Perspective

Cited by 9 publications

References 9 publications

Myt1l induced direct reprogramming of pericytes into cholinergic neurons

Myt1l induced direct reprogramming of pericytes into cholinergic neurons

Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases?

Treatment of Parkinson’s disease using human stem cells

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