Stem cells and biopharmaceuticals: Vital roles in the growth of tissue-engineered small intestine

Intestinal Failure/Nontransplant surgical interventions for short bowel syndrome

“…İnce bağırsak doku muhendisliği çalışmaları (Tissue Engineering Small Intestine=TESI): yeni kompleks bir alandır, bu amaçla sofistike materyaller, insan puluripotent kök hücreleri ve biyofarmasetik ajanlar denenmektedir (92) . Çalışmalarla villus benzeri yapılar oluşturulmuş, ancak henüz mezenkimal düzey oluş-turulamamıştır (93) .…”

Tissue Engineering Functional Gastrointestinal Regions: The Importance of Stem and Progenitor Cells

“…Short episodes of Wnt exposure are all that is needed for embryonic development and likely this is all that would be needed in tissue engineering as well (Zimmerman et al 2012). Wnt has a broad range of targets and responses, however, making it undesirable for clinical application in engineering human tissue, but R-spondins have potential to more specifically enhance engineered intestinal growth (Belchior et al 2014).…”

Short-Bowel Syndrome in Children — An Update in Management Strategies

“…Tissue engineering is also reviewed; this novel strategy, currently in its exploratory phase, aims to build a new small bowel [47].…”

“…In order to build a viable and functional small intestine, the armamentarium of TESI includes sophisticated materials, human pluripotential stem cells, and biopharmaceutical means [100].…”