Stem Cells and Cartilage

Richardson, JB; Lim, Jtk; Hui, James; Lee, Eun Hui

doi:10.1142/9789812569370_0022

Cited by 1 publication

(2 citation statements)

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“…In detail, defects will cause chondrocyte cells to proliferate, regenerate cartilage matrix and produced fibrous cartilage tissue [7]. Knee joint cartilage does not have blood vessels and therefore lacks the ability to regenerate [9][10][11]. Until recently, treatments of knee joint cartilage defect have not involved the production of hyaline cartilage [3,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand the formation of cartilage was found to be affected by growth factors such as TGF-β1, IGF-1 and FGF which are also regulatory molecules in order to regulate cell behavior and increase chondrogenesis. [2,10,15,27]. Another important component is the availability of fibronectin in which will increase cell adhesion, migration and cell differentiation [28].…”

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confidence: 99%

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Hyaline Cartilage Regeneration on Osteochondral defects by Intraarticular Injection of Human Peripheral Blood CD34+ Cells, Hyaluronic Acid and Growth Factor in a Rat Model

Supartono

2018

BJSTR

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The knee joint cartilage often suffers from defect and it causes serious health problem. CD 34+ stem cells have been studied to heal bone fracture however the cells has never been studied to repair cartilage. This study also focuses on the use of scaffold and growth factor affecting the healing of cartilage defect using CD 34+ cells. This is the first study reporting hyaline cartilage regeneration on osteochondral defect with intra articular injection of human peripheral blood CD 34+ (HPB CD 34+ ) cellated on the trochlear region of Sprague Dawley (SD) rats. A total of 30 male SD rats were randomly divided into 3 groups; the control group received PBS, experimental group 1 received HPB CD 34+ cells, and experimental group 2 received HPB CD 34+ cells, hyaluronic acid, and growth factors (TGF-ß1, IGF-1, FGF, fibronectin). Laboratory, radiology, macroscopic and microscopic evaluations were done on week 4 th and 8 th . At week 4 th and 8 th , both experimental groups showed the defects fully filled with hyaline cartilage but not in control group. In conclusion, human peripheral blood CD 34+ stem cells can generates hyaline cartilage of osteochondral defects in a rat model.

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